Foreign scientists on the contribution of Serbian physician and scientist Dr. Lazar K. Lazarević to medical science.

Dr. Lazar K. Lazarević (1851-1890, Julian calendar/1891, Gregorian calendar) was an exceptional Serbian physician, scientist, writer and translator.

Lazar K. Lazarević, the author who first described the straight leg raising test.

Objective: To highlight the contributions of Lazar K. Lazarević (1851-1891), physician, scientist, writer, and translator in the field of neurology. During his brief period of professional activities, Lazar K.

Gender and stroke lateralization: factors of functional recovery after the first-ever unilateral stroke?

Purpose: The goal of this prospective study was to evaluate gender differences in rehabilitation outcome in patients after the first-ever unilateral stroke.

Methods: A total of eighty right-handed patients were prospectively enrolled, 35 (44%) women, and 45 (56%) men. A degree of neurological deficit was quantified by the National Institutes of Health Stroke Scale.

Gender-specific functional cerebral asymmetries and unilateral cerebral lesion sequelae.

The magnitude and direction of cerebral lateralization are thought to be sexually dimorphic. Numerous human studies indicate gender-specific differences in functional cerebral asymmetries (FCAs) for various functions. Females are thought to have a decreased magnitude of inter-hemispheric cortical lateralization compared with males, whereas males exhibit a greater degree of cortical asymmetry than females for components of cognitive and perceptual processing.

Are female sex steroids neuroprotective in experimental stroke.

The central nervous system and the peripheral nervous system are important targets of gonadal steroids, which affect brain development and differentiation, and influence neuronal functions. Most of the studies have shown that female sex steroids progesterone and 17beta-estradiol exert protective effects in the experimental models of stroke, although deleterious effects have also been reported. Extensive studies on female sex steroids in cerebral ischemia have described their potential to act on multiple ischemic injury pathways, and pointed out the significance of numerous factors, including gender, age, brain region, duration of ischemia, and precise dose of steroids.

Estriol and progesterone: a new role for sex hormones.

The physiological states pregnancy and parturition are undoubtedly associated with clinical changes of most of the autoimmune diseases. An altered Th1/Th2 balance has been proposed as an underlying mechanism. A pregnancy has protective effect on Th1-mediated autoimmune diseases, and a deteriorative effect on Th2-mediated autoimmune diseases.

Is pregnancy a model how we should control some autoimmune diseases?

Pregnancy and parturition are the physiological conditions that affect the course and severity of numerous autoimmune diseases. If genotype might be primarily considered as a determinant of whether or not autoimmunity develops, clinical heterogeneity of the disease might arise from the interaction of the genotype and the environment. Numerous external factors with extremely important immunoregulatory properties, including hormones, affect an in vivo open complex immune system.