In vitro and in silico analysis unravelled clinically desirable attributes of Bacillus altitudinis L-asparaginase.

Aims: To identify a marine L-asparaginase with clinically desirable attributes and characterize the shortlisted candidate through in silico tools.

Methods And Results: Marine bacterial strains (number = 105) isolated from marine crabs were evaluated through a stepwise strategy incorporating the crucial attributes for therapeutic safety. The results demonstrated the potential of eight bacterial species for extracellular L-asparaginase production.

Morphological and Molecular Characterization of Two New Species of Ceratomyxa Thélohan, 1892 (Cnidaria: Myxosporea) from the Marine Ornamental Fish Zanclus cornutus (Linnaeus, 1758) off Lakshadweep Islands, Arabian Sea.

Purpose: The present study provides the complete morphological and molecular description of two new species of myxosporeans, Ceratomyxa zancli n. sp. and Ceratomyxa cornuti n.

Description and development of Auerbachia ignobili n. sp. (Cnidaria: Myxosporea: Bivalvulida) from the giant trevally, Caranx ignobilis (Forsskål, 1775) from Indian waters.

The present study describes a new species of myxosporean, Auerbachia ignobili n. sp., infecting the hepatic bile ducts of Caranx ignobilis (Forsskål, 1775).

Outbreak of Parasitic Dinoflagellate sp. Infection in an Endangered Fish from India: Arulius Barb ().

Freshwater velvet disease is caused by the dinoflagellate parasite, sp. This parasite has been reported in tropical and subtropical fishes, and it can cause devastating losses. Moreover, sp.

Sphaeromyxa cornuti n. sp., a New Species of Myxosporean Infecting the Gallbladder of the Moorish Idol, Zanclus cornutus (Linnaeus, 1758) from Lakshadweep Waters.

Purpose: The present study describes a new species of myxosporean, Sphaeromyxa cornuti n. sp. infecting the gallbladder of the Moorish idol, Zanclus cornutus (Linnaeus 1758) collected from Lakshadweep waters of the Arabian Sea.

Hepatic microsporidiosis of mudskipper, Valenciennes, 1837 (Perciformes: Gobiidae), due to sp.

The present study reports a case of hepatic microsporidiosis caused by sp. in brackishwater fish, (Valenciennes, 1837) (n = 60), from the west coast of India. An eight-month study from September 2017 to April 2018 revealed a prevalence of 11.

Characterization of novel L-asparaginases having clinically safe profiles from bacteria inhabiting the hemolymph of the crab, Scylla serrata (Forskål, 1775).

L-asparaginase (ASNase) is the principal chemotherapeutic agent against different blood cancers. The risks associated with current clinical preparations demand screening for novel ASNases. Accordingly, the study was conducted to shortlist ASNases having clinically safer profiles from a novel niche, namely, microbes in the gut and hemolymph of apparently healthy Scylla serrata.

Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide.

Expansions of a GC repeat in the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two devastating adult-onset neurodegenerative disorders. Using C9-ALS/FTD patient-derived cells and C9ORF72 BAC transgenic mice, we generated and optimized antisense oligonucleotides (ASOs) that selectively blunt expression of GC repeat-containing transcripts and effectively suppress tissue levels of poly(GP) dipeptides. ASOs with reduced phosphorothioate content showed improved tolerability without sacrificing efficacy.

Morphological and molecular description of a new species of (Myxosporea: Myxobolidae) infecting (Smith, 1846) from India.

The present paper describes a novel species of parasitizing the gill filaments of the largescale mullet, from Cochin backwaters, Kerala, India. The parasite develops in the gill filaments; plasmodia elongated, milky white, measured 1.37-2.

Morphological and molecular characterization of Neoechinorhynchus (N.) cephali n. sp. (Acanthocephala: Neoechinorhynchidae) Stiles and Hassall 1905 infecting the flathead grey mullet Mugil cephalus (Linnaeus, 1758) from the southwest coast of India.

The present paper describes Neoechinorhynchus (Neoechinorhynchus) cephali n. sp., an acanthocephalan parasite infecting the intestine of the flathead grey mullet Mugil cephalus from the southwest coast of India.

Characterization of Filisoma argusum n. sp. (Acanthocephala: Cavisomatidae Meyer, 1932) infecting the spotted scat, Scatophagus argus (Linnaeus, 1766) from the Indian coast.

The present paper describes Filisoma argusum n. sp. (Cavisomatidae), an acanthocephalan parasite infecting the intestine of the spotted scat, Scatophagus argus (Linnaeus, 1766), in the south-west coast of India.

A novel ferritin subunit gene from Asian green mussel, Perna viridis (Linnaeus, 1758).

Iron sequestration through ferritin forms a major part of innate immune response in molluscs and detailed understanding of ferritin gene and its functions can be directly applied in infection and disease management studies. Accordingly, identification and detailed molecular characterization of a ferritin subunit gene from a commercially significant marine mussel Perna viridis was targeted. Molecular screening using degenerate primers in total mantle RNA resulted in the amplification of a novel ferritin gene fragment having <87% identity to the reported ferritin gene sequences.

Morphological and molecular characterization of Ceratomyxa xanthopteri n. sp. (Myxosporea: Ceratomyxidae) from the marine ornamental fish Acanthurus xanthopterus Valenciennes 1835 (Acanthuridae) off Vizhinjam coast, Kerala.

A new species of Ceratomyxa infecting the gallbladder of the marine ornamental fish Acanthurus xanthopterus collected from the Vizhinjam coast of Kerala is described. The parasite exhibited a prevalence of 100%. Mature spores recovered from the gallbladder were slightly crescentic with rounded lateral extremities and possessed convex anterior and slightly concave to straight posterior margins.

A novel myxozoan parasite, Ellipsomyxa boleophthalmi sp. nov. (Myxozoa: Ceratomyxidae) in the brackishwater fish, Boleophthalmus dussumieri Valenciennes, 1837 (Perciformes: Gobiidae) from India.

A novel myxozoan parasite is identified and described from mudskipper, Boleophthalmus dussumieri, collected from a brackishwater ecosystem in Maharashtra, India. Ellipsomyxa boleophthalmi sp. nov.

Ellipsomyxa ariusi sp. nov. (Myxosporea: Ceratomyxidae), a new myxosporean infecting the gallbladder of threadfin sea catfish Arius arius in India.

The present study describes a new species of myxosporean, Ellipsomyxa ariusi sp. nov., infecting the gallbladder of the threadfin sea catfish Arius arius (Hamilton, 1822).

Three new species of virgulate xiphidiocercariae infecting the freshwater snails of Kerala.

Three new species of virgulate xiphidiocercariae infecting the freshwater snails of Malabar, Kerala is described. sp. XXVI Malabar n.

Epizootics of epizootic ulcerative syndrome among estuarine fishes of Kerala, India, under post-flood conditions.

Epizootic ulcerative syndrome (EUS), primarily caused by the water mold Aphanomyces invadans, is an OIE-notifiable disease, having potential impacts on fisheries. We report EUS epizootics among estuarine fishes of Kerala, India, during 2018, under post-flood conditions 3 decades after its primary outbreak. Six fish species (Mugil cephalus, Platycephalus sp.

A new digenetic trematode n. sp. (Faustulidae) from the emperor angel fish from Gulf of Mannar, India.

n. sp. is described from the emperor angel fish collected from Gulf of Mannar and maintained in the marine aquarium at CMFRI, Mandapam, India.

Ortholinea scatophagi (Myxosporea: Ortholineidae), a novel myxosporean infecting the spotted scat, Scatophagus argus (Linnaeus 1766) from southwest coast of India.

A new species of myxosporean, Ortholinea scatophagi n. sp. infecting the urinary bladder of the spotted scat, Scatophagus argus (Linnaeus 1766) is described.

Four new species of virgulate xiphidiocercariae infecting the freshwater snail, () (Benson, 1836) in Malabar, Kerala.

The present paper describes four new species of virgulate xiphidiocercariae infecting the freshwater gastropod, () (Benson, 1836) collected from Malabar, Kerala. sp. XXII Malabar n.

New species of macrocercous and megalurus cercariae infecting the freshwater snail, (Gmelin, 1771) in Malabar, Kerala.

The present paper describes two new species of cercariae infecting the freshwater snail, from Malabar, Kerala. collected from the hill streams at Vattakkundu in the Wayanad district of Kerala harboured a macrocercous cercaria, sp. XX Malabar n.

Perkinsus olseni in the short neck yellow clam, Paphia malabarica (Chemnitz, 1782) from the southwest coast of India.

Parasites of the genus Perkinsus predominantly infect bivalves, and two species among them, P. olseni and P. marinus, are notifiable to OIE.

Morphological and molecular characterization of Chloromyxum argusi n. sp. (Myxosporea) infecting the urinary bladder of Scatophagus argus Linnaeus 1766 (Scatophagidae) from the southwest coast of India.

The present paper describes a new species of Chloromyxum infecting the urinary bladder of the estuarine fish, Scatophagus argus, from the southwest coast of India. The parasite exhibited an overall prevalence of 41.93%; the prevalence is influenced by host size and seasons.

Furcocercous cercariae infecting freshwater snails in Malabar: two new species from Lamarck and (Hutton).

The present paper describes two new species of furcocercous cercariae, sp. XVIII Malabar n. sp.

Two new species of furcocercous cercariae infecting the fresh water snail, (Müller) in Kozhikode and Malappuram districts of Kerala.

Two new species of furcocercous cercariae, sp. XVI Malabar n. sp.