Publications by authors named "Sangumani Jayaraman"
Purpose: The aim is to validate the third generation Thyrotropin receptor antibody (TRAb) assay for predicting neonatal thyroid dysfunction and adverse pregnancy outcomes in pregnant women with Graves' disease.
Methods: This prospective cohort study was conducted in TRAb positive pregnant women with Graves' disease and their off springs. The primary outcome was to assess different forms of neonatal thyroid dysfunction in relation to maternal and neonatal TRAb levels.
Highly Active Antiretroviral Therapy-associated Lipodystrophy: Pseudo-Cushing's Syndrome.
J Assoc Physicians India
February 2023
Article Synopsis
- Insulin resistance and hyperinsulinemia contribute to polycystic ovary syndrome (PCOS), and the study aimed to compare metformin alone against metformin combined with Myoinositol and d-chiro-inositol in treatment outcomes for PCOS patients.
- Conducted over 6 months, the randomized controlled trial included overweight and obese women aged 18-35 with PCOS, divided into two treatment groups to assess various health parameters.
- Results showed that both treatments improved menstrual cycle regularity, but the myoinositol group had significantly better outcomes in quality of life, while pregnancy rates were similar; other hormonal and metabolic improvements weren't statistically significant.
Aims And Objectives: Clinical, biochemical, and radiological profiles of Addison's disease and to assess the various etiological spectrum of primary adrenal insufficiency (PAI) in adults.
Materials And Methods: A retrospective cohort study was carried out in the Department of Endocrinology, Madurai Medical College, Madurai between January 2014 and January 2021 over a 7-year period.
Inclusion Criteria: All the patients with clinical symptoms and or signs of suspected PAI, such as hyperpigmentation, weight loss, persistent nausea or vomiting, fatigue, and hypotension, were recruited.
Aim: Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder of the adrenal steroidogenic pathway. The most common form of CAH is due to 21-hydroxylase deficiency resulting from mutations in gene. The present study aimed to identify common gene mutations, phenotype correlation, and to analyze the segregation pattern in CAH patients, parents, and siblings.
View Article and Find Full Text PDFDisorders of sexual development (DSDs) are heterogenous group of disorders characterized by discrepancy in chromosomal, gonadal, and phenotypic sex. DSD is a Medico-Social Emergency. 5 α reductase type 2 deficiency is one of the rare causes of 46 XY DSD.
View Article and Find Full Text PDFObjective: Hypophosphatemic rickets with hypercalciuria (HHRH) is a rare, recessively-inherited form of rickets caused by homozygous or compound heterozygous mutations in the gene that encodes the renal tubular phosphate transporter protein NaPi2c. The bone phenotype varies from severe rickets to no disease. Accurate diagnosis is important as the treatment differs from other forms of rickets.
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