Publications by authors named "Sangseob Kim"
Objective: Adipose tissue remodeling plays a critical role in obesity-induced metabolic dysfunction, but the underlying molecular mechanisms remain incompletely understood. This study investigates the role of miR-10a-5p in adipose tissue inflammation and metabolic dysfunction induced by a high-fat diet (HFD).
Methods: Male miR-10a knockout (KO) mice were fed a HFD to induce obesity for up to 16 weeks.
Article Synopsis
- Adipose tissue adjusts to excess calorie intake by using immune cells to replace unhealthy fat cells with new ones, particularly focusing on lipid-associated macrophages (LAMs) that are significant in obesity and inflammatory diseases.
- The study identifies TM4SF19, a protein found in LAMs, which prevents lysosome acidification; removing this protein enhances the process of clearing out damaged fat cells.
- Mice without TM4SF19 show more restorative macrophages and adapt to high-fat diets by increasing the number of fat cells (hyperplasia) instead of enlarging them (hypertrophy), leading to better insulin sensitivity and energy use as a possible strategy to fight obesity-related health issues.
Maintenance of appropriate muscle mass is crucial for physical activity and metabolism. Aging and various pathological conditions can cause sarcopenia, a condition characterized by muscle mass decline. Although sarcopenia has been actively studied, the mechanisms underlying muscle atrophy are not well understood.
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