Publications by authors named "Sangita Sethuram"
Objective: The burden of major depressive disorder is compounded by a limited understanding of its risk factors, the limited efficacy of treatments, and the lack of precision approaches to guide treatment selection. The Texas Resilience Against Depression (T-RAD) study was designed to explore the etiology of depression by collecting comprehensive socio-demographic, clinical, behavioral, neurophysiological/neuroimaging, and biological data from depressed individuals (D2K) and youth at risk for depression (RAD).
Methods: This report details the baseline sociodemographic, clinical, and functional features from the initial cohort (D2K N = 1040, RAD N = 365).
Article Synopsis
- Alterations in the gut microbiome are linked to mental illnesses like anxiety and depression, prompting a study on their influence on symptoms in depressed individuals.
- The research analyzed the gut microbiota of 179 participants with major depressive disorder using advanced sequencing and assessed their anxiety and depression severity through various scales.
- The findings revealed a significant co-occurrence network of specific bacterial taxa related to depression and anxiety, suggesting that decreased butyrate production might play a role in these clinical symptoms.
Depression has a chronic and recurrent course often with early onset and is the leading cause of disability worldwide. In contrast to diagnoses for other conditions which rely on precise medical tests, the diagnosis of depression still focuses exclusively on symptom reports. As a result, heterogeneous patient groups are included under broad categories.
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