Synthesis of quinazolinone scaffolds a zinc(II)-stabilized amidyl radical-promoted deaminative approach.

Herein, we report a solely ligand centered redox controlled protocol, utilizing a bench stable zinc compound, for the efficient coupling of -amino amides/esters with nitriles to afford diverse quinazolinone scaffolds and their synthetic utility was showcased post-modification to access therapeutically relevant compounds. Importantly, mechanistic probes established the reaction pathway that proceeds aminyl radical.

Unravelling a bench-stable zinc-amide compound as highly active multitasking catalyst for radical-mediated selective alk(en)ylation of unactivated carbocycles under mild conditions.

The direct functionalization of unactivated organic moieties C-C bond formation has long fascinated synthetic chemists. Although base-metal systems are steadily emerging in this area, achieving multitasking activity in a single catalyst to execute several such functionalizations under mild conditions is challenging. To address this, we herein report an effective protocol for the selective C-alk(en)ylation of indene/fluorene with alcohol as a green alkylating agent employing a naturally abundant and eco-friendly zinc-derived compound, for the first time.

Simple silver(I)-salt catalyzed selective hydroboration of isocyanates, pyridines, and quinolines.

AgSbF has been established as an effective catalyst for the hydroboration of structurally and electronically diverse isocyanates under ligand- and solvent-free conditions which selectively yielded either N-boryl formamides or N-boryl methylamines under different conditions. Further, various N-heterocycles can be selectively hydroborated using this simple catalytic system; pyridine derivatives undergo preferential 1,4 hydroboration whereas the formation of tetrahydroquinoline (after hydrolysis) complete heterocycle hydrogenation was observed for quinolines.