Publications by authors named "Sanggoo S Kim"
Bacteria have aggressive acquisition processes for iron, an essential nutrient. Siderophores are small iron chelators that facilitate cellular iron transport. The siderophore enterobactin is a triscatechol derivative of a cyclic triserine lactone.
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- Bacteria produce siderophores to obtain iron due to the insolubility of ferric ions in neutral pH, with chirality affecting cell interaction.
- Corynebactin, found in Gram-positive bacteria, has a structure similar to enterobactin but includes L-threonine and a glycine spacer, differentiating their properties.
- Molecular modeling reveals that enterobactin forms a Delta-ferric complex, while corynebactin forms a Lambda complex, and the hybrid serine-corynebactin shows a near-equal mix of both conformations due to slight energy differences.
Article Synopsis
- Many bacteria use siderophores to obtain iron, and the structure of these iron complexes influences how cells recognize and utilize them.
- Corynebactin, a siderophore from Gram-positive bacteria, is similar to enterobactin from Gram-negative bacteria but differs in its chemical structure.
- Research on the interactions and stability of ferric complexes shows that while enterobactin has one configuration, corynebactin has a Lambda configuration, and a hybrid version with serine produces a mix of structures with a slight preference for Lambda.