Role of prior immunity in binding to spike of "future" Omicron subvariants.

Background: Throughout the COVID-19 pandemic, virus evolution and large-scale vaccination programs have caused multiple exposures to SARS CoV-2 spike protein, resulting in complex antibody profiles. The binding of these to spike protein of "future" variants in the context of such heterogeneous exposure has not been studied.

Methods: We tested archival sera (Delta and Omicron period) stratified by anti-spike antibody (including IgG) levels for reactivity to Omicron-subvariants(BA.

Keratinizing pleomorphic adenoma: A rare variant in an unusual location.

Pleomorphic adenoma is the most common benign salivary gland tumour characterized by great histologic diversity. The presence of extensive squamous metaplasia and numerous keratin pearls is mostly uncommon in the microscopic study and can signify a potential pitfall in the histopathological diagnosis Pleomorphic adenoma can show the presence of squamous metaplasia with keratin pearls as a rare finding and is encountered most often in the parotid gland (84%) and 6% in the minor salivary gland. Here we present a case report of a rare histopathological variant of pleomorphic adenoma with exuberant squamous metaplasia and keratin pearl formation of the minor salivary gland in an unusual location.

Common mental disorders in South Asian patients with systemic sclerosis: a CIS-R-based cross-sectional study.

There are not many studies looking at psychological impact of physical morbidities amongst patients with systemic sclerosis. Our aim was to describe the prevalence of common mental disorders (CMD) in systemic sclerosis patients, as against the population prevalence of CMDs. We also wanted to assess the utility of revised clinical interview schedule (CIS-R), a standardised interview technique for screening CMDs in systemic sclerosis (SSc).

Validation of new classification criteria of rheumatoid arthritis in an international multicentre study.

Objectives: Early identification of patients with rheumatoid arthritis (RA) is essential to allow prompt therapy. In this study, we aimed to evaluate the performance of the newly proposed ERA criteria, compared to the 1987 ACR and 2010 ACR/EULAR criteria in an international multicentre study.

Methods: A total of 606 patients with disease duration ≤2 years and age ≥16 years who were diagnosed as RA or non-RA were enrolled from China, Sweden and India.