Publications by authors named "Sangeetha Mangalakumaran"
Article Synopsis
- Neutrophils are crucial in rheumatoid arthritis (RA) by releasing reactive oxygen species (ROS) and enzymes that damage joints; JAK inhibitors like tofacitinib and baricitinib can modify neutrophil function and improve RA symptoms.
- Clinical trials show that while JAK inhibitors are effective, they can increase infection rates and lead to temporary low neutrophil counts (neutropenia).
- This study found differences in energy metabolism between neutrophils from healthy individuals and those with RA, revealing that JAK inhibitors reduce ROS and NET production without compromising the neutrophils' ability to fight off bacteria, potentially helping to prevent joint damage.
