Publications by authors named "Sangee Woo"
Ethnopharmacological Relevance: Melissa officinalis L. (Labiatae; lemon balm) has been used traditionally and contemporarily as an anti-stress herb. Current hypotheses suggest that not only chronic stress promotes angiogenesis, but angiogenesis also modulates adipogenesis and obesity.
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- - The study investigates how ALS-L1023 (ALS), an antiangiogenic compound derived from Melissa leaves, influences fat tissue growth and obesity, focusing on its effects in high-fat diet-induced obese mice.
- - ALS was found to inhibit endothelial cell growth and reduce the activity of matrix metalloproteinases (MMPs) involved in tissue remodeling, leading to less body weight gain and smaller fat cells in treated mice.
- - Treatment with ALS also decreased levels of certain angiogenic factors and MMPs in adipose tissue while increasing levels of angiogenic inhibitors, suggesting that targeting angiogenesis can effectively reduce body fat in obesity-related conditions.
Ethnopharmacological Relevance: Adipocyte lipid accumulation due to impaired fatty acid oxidation causes adipocyte hypertrophy and adipose tissue increment, leading to obesity. The aim of this study was to determine the antiobesity effects of the herbal composition Gambigyeongsinhwan (4) (GGH(4)) composed of Curcuma longa L. (Zingiberaceae), Alnus japonica (Thunb.
View Article and Find Full Text PDFContext: The herbal composition Gyeongshingangjeehwan 18 (GGEx18) extracted from Rheum palmatum L. (Polygonaceae), Laminaria japonica Aresch (Laminariaceae), and Ephedra sinica Stapf (Ephedraceae) is traditionally used as an anti-obesity drug by local clinics in Korea.
Objective: This study investigates the effects of GGEx18 on visceral obesity and insulin resistance and determines the molecular mechanisms involved in this process.