Laxative Activity of the Hot-Water Extract Mixture of Thunb. and Mazel in Chronic Constipation Model SD Rats.

This study examined the laxative effects of hot-water extracts of Thunb. (HD), Mazel (PM), and a 2:8 mixture of both (HP) in two chronic constipation models. For the loperamide-induced constipation model, animals were divided into an untreated group, negative control group (loperamide 4 mg/kg), positive control group (bisacodyl 4 mg/kg) group, and six treatment groups (HP 100 or 400, HD 50 or 100, and PM 100 or 400 mg/kg).