Publications by authors named "Sang-No Lee"
This study estimated the population pharmacokinetics of risperidone and its active metabolite, 9-hydroxyrisperidone, according to genetic polymorphisms in the metabolizing enzyme (CYP2D6) and transporter (ABCB1) genes in healthy subjects. Eighty healthy subjects who received a single oral dose of 2 mg risperidone participated in this study. However, eight subjects with rare genotype variants in CYP2D6 alleles were excluded from the final model built in this study.
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- The study aimed to explore how genetic variations in the ABCB1 and CYP2D6 genes affect how the body processes risperidone, a medication used for psychiatric conditions.
- A group of 72 healthy Korean participants took a single dose of risperidone, showing significant differences in blood levels of the drug based on their ABCB1 gene variations.
- The results suggest that certain genetic profiles, especially ABCB1 3435C>T in individuals with low CYP2D6 activity, may influence the risk of adverse effects from risperidone.
Mycotoxins are commonly encountered natural products, and are capable of poisoning animals or humans that inhale mold particles from mycotoxin-contaminated foods. Ochratoxin A (OTA) is produced by Aspergillu ochracus and Penicillium verrucosum, and is often found in cereals and agricultural products. Although previous studies have focused on the potent nephrotoxicity and renal carcinogenicity of OTA, more recent studies suggest that it accumulates in the brain and causes oxidative stress and DNA damage in various brain regions and neuronal populations.
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