Publications by authors named "Sang-Ho Jeong"
There are no reports comparing diet recovery between patients who underwent distal gastrectomy (DG) and those who underwent total gastrectomy (TG). The aim of the present study was to compare dietary habits and nutritional status after curative treatment with DG and TG in patients with gastric cancer. We retrospectively collected clinical data from 263 consecutive patients who underwent gastrectomy for gastric cancer without recurrence at a single-center between January 2016 and December 2022.
View Article and Find Full Text PDF[...
View Article and Find Full Text PDFArticle Synopsis
- - Sentinel node navigation (SNN) is effective for stomach-preserving surgery in early gastric cancer but has technical challenges in practice.
- - A study analyzed data from the SENORITA trial, evaluating the effectiveness of regional lymphadenectomy without SNN on 237 patients, focusing on lymph node metastasis in relation to tumor location.
- - Results indicated that while SNN showed higher sensitivity and negative predictive values for detecting metastasis compared to regional lymphadenectomy, completely omitting SNN in surgery was deemed insufficient and not recommended.
This study investigates the role of SMARCD3 in gastric cancer by comparing its expression in signet ring cell (SRC) and well-differentiated (WD) groups within gastric cancer cell lines and tissues. We observed elevated SMARCD3 levels in the SRC group compared to the WD group. Functional analysis was conducted through both SMARCD3 knock-in and knock-out methods.
View Article and Find Full Text PDFBackground/objective: This study aimed to compare complication rates between pylorus-preserving gastrectomy (PPG) and distal gastrectomy (DG) using Korean nationwide survey data and propensity score weighting (PSW). PPG preserves gastric function but may lead to more postoperative complications than DG.
Methods And Results: We analyzed 9424 gastric cancer patients who underwent either DG ( = 9183) or PPG ( = 241).
Article Synopsis
- The SENORITA trial aimed to evaluate the quality of life (QoL) and nutritional outcomes of patients undergoing two types of surgeries: laparoscopic sentinel node navigation surgery (LSNNS) and laparoscopic standard gastrectomy (LSG).
- The objective was to compare long-term QoL and nutritional outcomes between patients who had stomach-preserving surgery and those who underwent standard gastrectomy, as well as to identify factors affecting QoL in the stomach-preserving group.
- The analysis included 194 patients who underwent stomach-preserving surgery and 257 who had standard gastrectomy, with findings indicating that the stomach-preserving group experienced better QoL scores three months post-surgery.
HTATIP2 Overexpression was Associated With a Good Prognosis in Gastric Cancer.
Technol Cancer Res Treat
February 2024
Article Synopsis
- The study aimed to compare the genetic profiles of poorly cohesive carcinoma (PCC) and well-differentiated tubular adenocarcinoma (WD) in gastric cancer, focusing on the role of the HIV-1 Tat Interactive Protein 2 (HTATIP2).
- Using next-generation sequencing and immunohistochemistry on gastric cancer tissue and cell lines, researchers found that HTATIP2 and other genes showed reduced expression in PCC compared to WD.
- The analysis revealed that higher levels of HTATIP2 were linked to better patient outcomes, including early-stage cancer and lower lymph node metastasis, suggesting it could serve as a promising prognostic marker and treatment target for gastric cancer.
Article Synopsis
- This study compared laparoscopic standard gastrectomy (LSG) and laparoscopic sentinel node navigation surgery (LSNNS) for early gastric cancer (EGC) to assess their long-term oncologic outcomes over 5 years.
- The SENORITA trial did not demonstrate that LSNNS was non-inferior to LSG; while 5-year disease-free survival (DFS) was similar between the two groups, LSNNS had a higher occurrence of gastric cancer-related events.
- The conclusion suggests that despite no significant differences in 5-year DFS, overall survival (OS), and disease-specific survival (DSS) between LSG and LSNNS, LSNNS may offer benefits in postoperative quality of life and
Article Synopsis
- - This study investigates Petersen's hernia, which can occur after specific types of stomach surgeries, and compares two methods for preventing bowel obstruction caused by this hernia: the conventional defect closure method and the newer mesenteric fixation method.
- - Conducted as a randomized controlled trial in Korea, the research includes patients with diagnosed gastric cancer who have undergone certain types of surgical anastomosis and aims to determine the effectiveness of each method in preventing bowel obstruction over a three-year period.
- - Results from this trial are expected to provide valuable insights on the efficacy and safety of the mesenteric fixation method, potentially establishing it as a superior technique for closing Petersen's defects.
Article Synopsis
- The study aimed to compare outcomes of laparoscopic primary repair (LPR) versus LPR combined with highly selective vagotomy (LPR-HSV) in patients with perforated duodenal ulcers.
- A total of 184 patients were analyzed, revealing that LPR-HSV had a longer operation time but significantly shorter hospital stays and quicker recovery in starting soft diets compared to LPR.
- The findings suggest that LPR-HSV could be a safe option for patients at high risk of ulcer recurrence, without significant differences in complication rates.
Purpose: This study aimed to analyze the incidence and risk factors of complications following gastric cancer surgery in Korea and to compare the correlation between hospital complications based on the annual number of gastrectomies performed.
Materials And Methods: A retrospective analysis was conducted using data from 12,244 patients from 64 Korean institutions. Complications were classified using the Clavien-Dindo classification (CDC).
Anastomotic leakage is one of the common causes of serious morbidity and death after gastrectomy. The use of surgical treatment for leakage decreased due to the development of nonsurgical management. However, if nonsurgical management fails to control the spread of intra-abdominal infection, emergency surgical treatment is required.
View Article and Find Full Text PDFArticle Synopsis
- - Ectopic thymic neoplasm, specifically ectopic thymic carcinoma, is a rare type of cancer that commonly presents as a mass in the neck.
- - A case study details a 65-year-old man who experienced persistent hoarseness and was later diagnosed with ectopic thymic squamous carcinoma after undergoing fine needle aspiration.
- - Following a total thyroidectomy and lymph node dissection, the patient recovered well, received adjuvant radiation therapy, and showed no progression of the disease during a 1-year follow-up.
Breast malignancy remains one of the most common causes of cancer-associated mortalities among women. MicroRNA (miR)-221 and miR-222 are homologous miRs and have a substantial impact on cancer progression. In the present study, the regulatory mechanisms of miR-221/222 and its target annexin A3 (ANXA3) in breast cancer cells were investigated.
View Article and Find Full Text PDFPurpose: By analyzing sentinel basin dissection (SBD) data from the SEntinel Node ORIented Tailored Approach (SENORITA) trial, we sought to determine the precise extent of the sentinel basin (SB) without a tracer.
Materials And Methods: This study investigated SB length in patients (n = 25) who underwent laparoscopic SBD for early gastric cancer (EGC) in the SENORITA trial. SB length along the greater curvature (GC) and lesser curvature (LC) was measured intraoperatively before performing SBD.
Article Synopsis
- - This study examined the relationship between red blood cell distribution width (RDW) and the RDW-to-platelet count ratio (RPR) with the prognosis of breast cancer in patients both before and after treatment.
- - Researchers analyzed data from 395 breast cancer patients, finding that elevated RPR and RDW levels post-treatment were significant indicators of poorer disease-free survival (DFS) and overall survival (OS).
- - The findings suggest that tracking RDW and RPR after treatment can provide important prognostic information for patients with breast cancer, potentially guiding future treatment options.
Adjuvant chemotherapy (AC) regimens tegafur/gimeracil/oteracil (S-1) and capecitabine plus oxaliplatin (CAPOX) have predominated, however, there has been a lack of studies on their differences in efficacy. We conducted pairwise meta-analyses comparing the efficacy of S-1 and CAPOX regimens for overall survival (OS) and disease-free survival (DFS) in stage II or III GC patients. Three studies were enrolled and analyzed using a forest plot for meta-analysis.
View Article and Find Full Text PDFCyclin D1 Serves as a Poor Prognostic Biomarker in Stage I Gastric Cancer.
Curr Issues Mol Biol
March 2022
TNM stage still serves as the best prognostic marker in gastric cancer (GC). The next step is to find prognostic biomarkers that detect subgroups with different prognoses in the same TNM stage. In this study, the expression levels of epidermal growth factor receptor (EGFR) and cyclin D1 were assessed in 96 tissue samples, including non-tumorous tissue, adenoma, and carcinoma.
View Article and Find Full Text PDFBackground: To analyze the short- and long-term clinical outcomes of 2 reconstruction methods after distal gastrectomy for gastric cancer.
Methods: Three keywords, "gastric neoplasm," "distal gastrectomy," and "reconstruction," were used to search PubMed. We selected only randomized controlled trial that compared the anastomosis methods.
Purpose: Tegafur/gimeracil/oteracil (S-1) and capecitabine plus oxaliplatin (CAPOX) are standard adjuvant chemotherapies (ACs) administered after gastrectomy to patients with stage II or III gastric cancer. However, the efficacy of AC in elderly patients remains unclear. The objective of this retrospective multicenter cohort study was to compare the efficacies of S-1 and CAPOX AC in patients aged ≥70 years.
View Article and Find Full Text PDFArticle Synopsis
- The study compared postoperative results between laparoscopic sentinel node navigation surgery (LSNNS) and laparoscopic standard gastrectomy (LSG) in patients with early-stage gastric cancer, focusing on outcomes like complications, survival rates, and quality of life (QOL).
- Among the 527 patients analyzed, the 3-year disease-free survival (3y-DFS) was slightly higher in the LSG group (95.5%) compared to the LSNNS group (91.8%), but LSNNS showed better physical function and nutritional outcomes.
- Though LSNNS didn’t meet the noninferiority criteria for 3y-DFS, both groups had
Article Synopsis
- - A 65-year-old woman developed skin changes, including hyperpigmentation and thickening, in her breast 10 years after having breast-conserving surgery and radiotherapy for cancer, raising concerns about several potential conditions including post-irradiation morphea and recurrent cancer.
- - Despite magnetic resonance imaging (MRI) showing no abnormalities, the patient experienced pain and worsening skin symptoms, leading to a simple mastectomy, which revealed oleoma and post-radiation fibrosis.
- - The case emphasizes the challenges in differentiating between post-irradiation morphea and oleoma due to the patient's complex medical history, highlighting the need for a multidisciplinary approach to ensure accurate diagnosis.
The aim of this study was to perform a clinicopathologic analysis of PHLPP1 expression in gastric cancer patients and analyze AKT activity with chemotherapy drug treatment in cancer subtypes. Surgically resected gastric cancer tissue specimens were obtained from 309 patients who underwent gastrectomy, and PHLPP1 expression was validated by tissue microarray analysis with immunohistochemistry. We assessed whether PHLPP1 selectively dephosphorylates Ser473 of AKT in an in-vitro study.
View Article and Find Full Text PDFSchwannoma of the breast presenting as a painful lump: A case report.
Medicine (Baltimore)
December 2021
Article Synopsis
- Schwannomas in the breast are rare tumors, typically found in other areas like the head and limbs.
- A case study focused on a 60-year-old woman who presented with a painful, palpable breast mass, which was diagnosed as a schwannoma via core needle biopsy.
- The patient underwent successful wide excision of the tumor with no complications, and a follow-up at six months showed no recurrence, highlighting the importance of considering schwannoma when assessing certain breast lesions.
Introduction: Patients who underwent curative gastrectomy for gastric cancer are regularly followed-up for the early detection of recurrence and postoperative symptom management. However, there is a lack of evidence with regard to proper surveillance intervals and diagnostic tools. This study aims to evaluate whether frequent surveillance tests have a survival benefit or improve the quality of life in patients who underwent curative resection for advanced gastric cancer.
View Article and Find Full Text PDF