Publications by authors named "Sang-Chol Lee"
Correction: 2023 Korean Society of Echocardiography position paper for diagnosis and management of valvular heart disease, part I: aortic valve disease.
J Cardiovasc Imaging
November 2024
Article Synopsis
- Osimertinib, a treatment for advanced non-small cell lung cancer, demonstrated a 4.7% incidence of cardiotoxicity in real-world settings, raising concerns about its long-term safety.
- The study analyzed 1,126 patients and identified risk factors for cardiotoxicity, including older age, previous heart failure, atrial fibrillation, and low left ventricle strain.
- A high recovery rate of 82.4% for cardiac dysfunction was observed, indicating potential reversibility, but emphasizes the need for careful monitoring in at-risk patients.
Article Synopsis
- Hypertrophic cardiomyopathy (HCM) is a condition with different forms and varying risks for sudden cardiac death (SCD), and this study aimed to categorize these forms based on their SCD-related features and outcomes.
- Researchers analyzed data from 1,231 HCM patients and identified three distinct groups: young patients with low SCD risk (Group 1), young patients with high SCD risk (Group 2), and older patients (Group 3) who faced different rates of SCD and other complications.
- The findings suggest that using these clear phenotypes can help better assess risks and manage patients with HCM more effectively.
Article Synopsis
- The Korean Society of Echocardiography outlines its official stance on valvular heart diseases, emphasizing clinical management.
- The paper references recent guidelines from major cardiac organizations, including the American College of Cardiology and the European Society of Cardiology.
- Part I of the article specifically focuses on aortic valve disease and its current situation in Korea, incorporating new research findings and Korean data.
Article Synopsis
- Aortic stenosis (AS) is common in older adults and more patients will need noncardiac surgeries, yet research on complications specifically in asymptomatic significant AS patients is limited.
- A study analyzed 221 patients with asymptomatic significant AS and found no significant difference in major cardiovascular events compared to a control group undergoing similar surgeries.
- Advanced cardiac damage stage in patients with significant AS emerged as a crucial factor influencing the risk of complications during noncardiac surgery.
Article Synopsis
- Chronic thromboembolic pulmonary disease (CTEPD) can restrict exercise even when patients show normal right ventricular (RV) function or no pulmonary hypertension at rest, making the combination of exercise stress echocardiography and cardiopulmonary exercise testing (ESE-CPET) valuable for evaluation.
- In a study involving 50 CTEPD patients with mild disease, results showed decreased maximal oxygen consumption (peak VO) and a significant increase in RV systolic pressure (RVSP) during exercise, indicating altered heart responses to physical activity.
- The findings suggest that patients with mild pulmonary hypertension or no hypertension still experience exercise limitations, with RV dysfunction becoming evident during exercise, particularly in those with impaired exercise capacity.
Article Synopsis
- Early atrial fibrillation (AF) events during the blanking period after total thoracoscopic ablation (TTA) are associated with a higher risk of late AF recurrence, highlighting the importance of monitoring these patients.
- In a study of 128 patients, 32.8% experienced early recurrence (ER) of AF, which significantly increased their risk of AF recurrence over 5 years compared to those without ER.
- Among patients with ER, left atrial (LA) strain proved to be an independent predictor of long-term AF recurrence, with those having LA strain below 18.6% showing a much higher risk of recurrence.
Background: The 2020 American Heart Association (AHA)/American College of Cardiology (ACC) guidelines for sudden cardiac death (SCD) risk stratification in hypertrophic cardiomyopathy (HCM) need further international validation.
Objectives: Performance of the guidelines and the incremental value of myocardial strain for predicting SCD in HCM were investigated.
Methods: In 1,416 HCM patients, SCD risk was stratified according to the 2020 AHA/ACC and 2014 European Society of Cardiology (ESC) guidelines.
Backgrounds: Myocardial injury after non-cardiac surgery (MINS) has recently been accepted as a common complication associated with increased mortality. However, little is known about the treatment of MINS. The aim of this study was to investigate an association between antiplatelet therapy and long-term mortality after MINS.
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- A study investigated the role of left atrial appendage emptying velocity (LAAV) as a predictor of atrial fibrillation (AF) recurrence in patients undergoing totally thoracoscopic ablation (TTA).
- Data was collected from 129 patients who underwent TTA, with findings indicating that lower LAAV was linked to higher rates of AF recurrence over a 3-year follow-up.
- Patients with a LAAV below 20 cm/s had significantly worse event-free survival compared to those with higher LAAV, suggesting LAAV can help identify patients at risk for AF recurrence post-TTA.
Article Synopsis
- The study investigates the impact of pericardial calcification patterns on the success of pericardiectomy for treating constrictive pericarditis (CP).
- Researchers analyzed preoperative CT scans and medical records of 98 patients who underwent the surgery from 2010 to 2020.
- Results indicate that patients with lower pericardial calcium scores experienced a higher rate of cardiovascular events post-surgery, suggesting that lower calcification may lead to worse outcomes.
Article Synopsis
- Left atrial (LA) fibrosis severity is linked to atrial fibrillation (AF) recurrence, with a study examining this relationship in patients who had thoracoscopic ablation surgery for AF.
- Among 128 patients, those with mild LAA fibrosis experienced lower AF recurrence rates (23.3%) compared to those with moderate (51.4%) and severe fibrosis (53.2%).
- The only significant predictor of mild fibrosis was peak LA strain, with a cutoff of 14.7%, indicating that higher strain levels correlate with better outcomes and lower AF recurrence risk after 5 years.
We aimed to evaluate the additive value of cardiovascular magnetic resonance imaging (CMR) and cardiopulmonary exercise test (CPET) to predict clinical outcomes in patients with HCM. We enrolled 373 patients with HCM and normal left ventricular systolic function who underwent CPET and CMR. The primary outcome was a clinical composite of all-cause death, cardiac transplantation, stroke, heart failure requiring hospitalization and defibrillator implantation.
View Article and Find Full Text PDFBackground: Myocardial injury after non-cardiac surgery (MINS) has recently been accepted as a predictor of mortality. However, sex differences in the incidence of MINS and survival thereafter are not fully understood. This study aimed to compare the incidence of MINS and mortality among male and female patients.
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- - The study investigates long-term cardiac and cerebrovascular risks in patients with hypertrophic cardiomyopathy (HCM) who have apical aneurysms (AAn), finding that AAn occurs in about 9.2% of patients.
- - Patients with AAn experience higher rates of major adverse cardiac and cerebral events (MACCEs) compared to those without AAn, particularly noting a significant difference in the rate of cerebrovascular accidents.
- - Larger AAn (Grade 2) correlates to an even greater risk of MACCEs, emphasizing that AAn significantly heightens the chances of adverse health outcomes, especially strokes, in patients with HCM.
Article Synopsis
- The study assessed the effectiveness of transesophageal contrast echocardiography (TECE) with the agitated saline test for diagnosing pulmonary arteriovenous malformations (PAVMs), comparing it to traditional methods like chest CT and pulmonary angiography.
- Out of 1,809 patients tested, 387 showed signs of PAVMs, with results indicating that TECE's grading system helps identify the severity and presence of PAVMs, with positive predictive values increasing with higher grades.
- The conclusion highlighted that TECE is a valuable diagnostic tool for non-HHT patients suspected of having PAVMs, suggesting those with lower grade findings might avoid unnecessary radiation exposure from further imaging tests.
Aims: Tricuspid valve (TV) surgery for functional tricuspid regurgitation (TR) is becoming more common, but the associated mortality remains high. Therefore, we evaluated the clinical and echocardiographic parameters associated with all-cause mortality in patients with severe functional TR who underwent TV surgery.
Methods And Results: A total of 286 patients with severe functional TR who underwent TV replacement or repair was analysed between January 2006 and December 2017.
Hypertrophic cardiomyopathy (HCM) is one of the most common inheritable cardiomyopathies. Contemporary management strategies, including the advent of implantable cardioverter-defibrillators and effective anticoagulation, have substantially improved the clinical course of HCM patients; however, the disease burden of HCM is still high in Korea. Sudden cardiac death (SCD), atrial fibrillation and thromboembolic risk, dynamic left ventricular outflow tract (LVOT) obstruction, and heart failure (HF) progression remain important issues in HCM.
View Article and Find Full Text PDFSerum sex hormones are known to be associated with cardiovascular disease (CVD), but effects in healthy men on cardiac function have not been well quantified. The authors sought to evaluate an association of sex hormones with cardiac structure and function. Study participants were 857 Korean men without significant cardiovascular diseases participating in the Healthy Twin Study.
View Article and Find Full Text PDFTo evaluate variations in pre-contrast (preT1) and post-contrast (postT1) myocardial T1 values and extracellular volume fraction (ECV) according to left ventricular (LV) segments and to find correlations between them and cardiovascular risk factors. The 233 asymptomatic subjects (210 men, 23 women; aged 54.1 ± 6.
View Article and Find Full Text PDFThe optimal blood pressure (BP) target in older people according to frailty status remains uncertain. This article investigates how frailty affects the association between BP and cardiovascular diseases or mortality, specifically in young-old adults. A retrospective cohort was created for 708,964 older adults with a uniform age of 66 years.
View Article and Find Full Text PDFDeterminants of Exercise Capacity in Patients With Hypertrophic Cardiomyopathy.
J Korean Med Sci
February 2022
Background: Reduced exercise capacity reflects symptom severity and clinical outcomes in patients with hypertrophic cardiomyopathy (HCM). The present study aimed to identify factors that may affect exercise capacity in patients with HCM.
Methods: In 294 patients with HCM and preserved left ventricular (LV) ejection fraction, we compared peak oxygen consumption (peak VO) evaluated by cardiopulmonary exercise testing as a representative parameter of exercise tolerance with clinical and laboratory data, including N-terminal pro-hormone of brain natriuretic peptide (NT-proBNP), diastolic parameters on echocardiography, and the grade of myocardial fibrosis on cardiac magnetic resonance imaging (CMR).
Background: We aimed to clarify the sex differences in various cardiovascular and non-cardiovascular outcomes, and to investigate whether sex differences in outcomes are affected by age in hypertrophic cardiomyopathy (HCM).
Methods: A cohort of 835 patients with HCM initially evaluated during 2007-2019 were followed for a median of 6.4 years.
Little is known about causality and the pathological mechanism underlying the association of serum lactate with myocardial injury in patients with acute myocardial infarction (AMI). We evaluated data from 360 AMI patients undergoing percutaneous coronary intervention (PCI) using cardiovascular magnetic resonance imaging (CMR). Of these, 119 patients had serum lactate levels > 2.
View Article and Find Full Text PDFBackground: Little is known about the causality and pathological mechanism underlying the association between old age and myocardial injury in patients with ST-segment elevation myocardial infarction (STEMI). We evaluated the association between old age and myocardial injury in STEMI patients undergoing primary percutaneous coronary intervention (PCI) using cardiovascular magnetic resonance imaging (CMR).
Methods: A total of 279 patients with STEMI who underwent primary PCI and CMR were enrolled.