Phenylpropanoids and polyacetylenes from the roots of .

Phytochemical investigation of the roots of yielded a new phenylpropanoid, adenophoride () and a new polyacetylene, adenylene () along with four phenylpropanoids and a polyacetylene. The structures were determined by spectroscopic analysis including NMR, MS, UV and IR. Among the isolated compounds, phenylpropanoids including a new compound showed mild α-glucosidase inhibitory activities.

Adenosine Deaminase Inhibitory Activity of Medicinal Plants: Boost the Production of Cordycepin in .

Cordycepin, also known as 3'-deoxyadenosine, is a major active ingredient of with diverse pharmacological effects. Due to its limited supply, many attempts have been conducted to enhance the cordycepin content. As part of this study, eight medicinal plants were supplemented with cultivation substrates of to increase the cordycepin content.

Polyacetylenes from the adventitious roots of Centella asiatica with glucose uptake stimulatory activity.

Centella asiatica (L.) Urban is an herbaceous perennial plant of the Apiaceae family that has diverse medicinal uses. Its active components are saponin, phenolics, and polyacetylenes.

mushroom with increased cordycepin content by the cultivation on edible insects.

Cordycepin is the major constituent of mushroom (or ) with therapeutic potential. Insects are the direct sources of nutrients for in nature. Therefore, optimized condition of cultivation for efficient cordycepin production was explored using six edible insects as substrates.

Therapeutic Potentials of Secoiridoids from the Fruits of Aiton against Inflammation-Related Skin Diseases.

Aiton is a flowering plant of the Oleaceae family, and its fruits have been traditionally used for skin nourishment and the treatment of skin diseases. However, the anti-inflammatory constituents for skin disease are not well-characterized. Phytochemical investigation of fruits resulted in the isolation of a new secoiridoid, secoligulene (), together with ()-3-(1-oxobut-2-en-2-yl)pentanedioic acid () and -()-3-(1-oxobut-2-en-2-yl)glutaric acid ().

Alpinumisoflavone ameliorates choroidal neovascularisation and fibrosis in age-related macular degeneration in in vitro and in vivo models.

Age-related macular degeneration (AMD) is a major cause of vision loss in the elderly population. Anti-vascular endothelial growth factor (VEGF) antibody therapy is applicable to neovascularisation of AMD; however, the prevention of fibrosis after anti-VEGF monotherapy is an unmet medical need. Subretinal fibrosis causes vision loss in neovascular age-related macular degeneration (nAMD) even with anti-VEGF therapy.

Aromatic Constituents from the Leaves of with Antioxidant and α-Glucosidase Inhibitory Activity.

As the leaf of has shown antioxidant activity, a study was conducted to identify the active ingredients. Forty-eight compounds were isolated from the leaves of through various chromatographic techniques. Further characterization of the structures on the basis of 1D and 2D NMR and MS data identified several aromatic compounds, including phenylpropanoid derivatives, phenolics, coumarins, flavonoids and lignans.

Anti-α-glucosidase and anti-oxidative isoflavonoids from the immature fruits of Maclura tricuspidata.

The composition of a plant, together with its efficacy, vary depending on its maturity and plant parts. In this study, the chemical constituents of immature fruits of Maclura tricuspidata (Moraceae) were investigated together with their anti-diabetic and antioxidant effects. A total of 34 compounds were isolated from the immature fruits of M.

Anti-diabetic potential of Masclura tricuspidata leaves: Prenylated isoflavonoids with α-glucosidase inhibitory and anti-glycation activity.

Investigation of chemical constituents of Masclura tricuspidata leaves resulted in the isolation of 47 isoflavonoids possessing prenyl groups with different numbers and structures. Among them, sixteen compounds named cudracusisoflavones A-P (1-16) were first isolated from nature. The isoflavonoids isolated from M.

Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus.

Four compounds, hericerin (1), isohericerinol A (2), N-de-phenylethyl isohericerin (3) and corallocin A (4) were isolated from the fruiting bodies of Hericium erinaceus, a lion's mane mushroom (Hericiaceae). Among them, isohericerinol A (2) was newly reported in nature. Further investigation of the neurotrophic effect of isolated compounds demonstrated that isohericerinol A (2) strongly increased the nerve growth factor (NGF) production in C6 glioma cells followed by corallocin A (4) and hericerin (1).

Phenylpropanoid-Conjugated Triterpenoids from the Leaves of and Their Inhibitory Activity on α-Glucosidase.

, commonly called hardy kiwifruit or kiwiberry, has cold-resistant properties and can be cultivated in Asia, including Korea. Seven new triterpenoids (- and -) along with eight known triterpenoids were isolated from the leaves of through various chromatographic techniques. The new triterpenoids were defined as actiniargupenes A-C (-), actinidic acid derivatives with phenylpropanoid constituent units, dehydroisoactinidic acid (), and actiniargupenes D-F (-), asiatic acid derivatives with phenylpropanoid substituents, on the basis of 1D and 2D NMR and MS data.

Organic acid conjugated phenolic compounds of hardy kiwifruit (Actinidia arguta) and their NF-κB inhibitory activity.

Nine new compounds, argutinosides A-I (1-9) together with 20 known compounds (10-29), were isolated from the fruits of Actinidia arguta. Using spectral analysis, the structures of the isolated compounds were identified as 10 succinic acid derivatives, 11 quinic acid derivatives, two shikimic acid derivatives and six citric acid derivatives. The NF-κB transcriptional inhibitory activity of the compounds was evaluated using RAW 264.