The therapeutic effects on U87 and SAS cells using Proton Linac based Boron Neutron Capture Therapy in Korea.

A proton linac based boron neutron capture therapy system (A-BNCT, 10MeV, 4mA) was successfully developed in Korea. We performed in vitro experiments with U87 and SAS cells and revealed the efficacy of a binary therapy BNCT using epithermal neutrons and boronophenylalanine (BPA). The results revealed that BNCT showed cancer cell selectivity and caused cell death.

The Anti-Tumor Effect of Boron Neutron Capture Therapy in Glioblastoma Subcutaneous Xenograft Model Using the Proton Linear Accelerator-Based BNCT System in Korea.

Boron neutron capture therapy (BNCT) is a radiation therapy that selectively kills cancer cells and is being actively researched and developed around the world. In Korea, development of the proton linear accelerator-based BNCT system has completed development, and its anti-cancer effect in the U-87 MG subcutaneous xenograft model has been evaluated. To evaluate the efficacy of BNCT, we measured B-enriched boronophenylalanine (BPA) uptake in U-87 MG, FaDu, and SAS cells and evaluated cell viability by clonogenic assays.

Multi-channel plastic-scintillator-based detection system for monitoring tritium in air.

To overcome the limitations of the ionization chamber-based tritium monitor, a design for a multichannel plastic scintillator-based detection chamber for monitoring tritium in air is proposed. The performance of the chamber was characterized by Monte Carlo-based calculations with various design parameters such as thickness of the plastic scintillator (t) and number of channels (n). We considered the volume and detection efficiency of the chamber to evaluate the performance of the detector.

Defect study on polyaniline by positron annihilation spectrometry.

Fast coincidence system was constructed and applied to positron annihilation spectrometry (PAS). We studied on the factors that affected the time resolution of the system. Time resolutions were obtained and mutually compared with respect to several factors such as sizes, kinds of scintillators, length dependence of delay lines on the CFD583, and width variations of the windows for 511keV and 1.