Publications by authors named "Sang Hyeop Lee"
Article Synopsis
- Antisense transcription has been found to be more common than initially thought since its discovery in bacteria in the 1980s, yet its functional importance remains debated.
- A study analyzed 3469 sense-antisense gene pairs in colorectal cancer (CRC) samples, revealing that cancer-related genes are more significantly correlated in these pairs compared to non-cancer genes.
- The findings indicate that the correlation strength between sense-antisense pairs can predict CRC prognosis, with stronger correlations linked to poorer outcomes, highlighting the regulatory role of antisense transcripts.
Article Synopsis
- Obesity leads to chronic low-grade inflammation in adipose tissue, prompting an investigation into gene expression differences between lean and obese individuals using mRNA sequencing.
- Significant findings indicated that inflammatory genes, such as IL-6 and TNF-α, were expressed at lower levels in obese adipocytes compared to lean ones, but some inflammatory genes were higher in obese preadipocytes.
- Overall, the study suggests that lean adipogenesis may involve a stronger inflammatory response than that seen in obese adipogenesis.
Tobacco smoking, a risk factor for several human diseases, can lead to alterations in DNA methylation. Smoking is a key source of cadmium exposure; however, there are limited studies examining DNA methylation alterations following smoking-related cadmium exposure. To identify such cadmium exposure-related DNA methylation, we performed genome-wide DNA methylation profiling using DNA samples from 50 smokers and 50 non-smokers.
View Article and Find Full Text PDFPurpose: This study examined the rate of degeneration of acetabular cartilage by the bipolar head according to time, and also which clinical factors are related to the degeneration of acetabular cartilage.
Materials And Methods: Among 192 patients (226 hip joints) who received bipolar hemiarthroplasty from August 1996 to August 2002, 61 patients (65 hip joints) were enrolled in this study, who were followed up for more than 2 years and showed no signs of dislocation, infection, or functional problems. A modified form of a computer assisted vector wear analysis program was used to measure the rate of degeneration of the acetabular cartilage.