Mevinolin enhances osteogenic genes (ALP, type I collagen and osteocalcin), CD44, CD47 and CD51 expression during osteogenic differentiation.

Aims: In this study, we evaluated the effect of mevinolin on the expressions of osteogenic genes and surface molecules expression during osteogenesis.

Main Methods: D1 cells were cultured in osteogenic differentiation medium (ODM) for 6 days, treated with mevinolin for 2 days, and then subjected to alizarin red S staining, MTT assays, alkaline phosphatase (ALP) activity determinations, energy dispersive X-ray spectrophotometry (EDX), real-time PCR, Western blot, fluorescence microscopy and FACS analysis.

Key Findings: Mevinolin is commonly prescribed and widely used to lower cholesterol levels, and offers an important, effective approach to the treatment of hypercholesterolemia and arteriosclerosis.

Perioperative complications of HINTEGRA total ankle replacement: our initial 50 cases.

Background: The purpose of the present study was to report the perioperative complications that occurred among our initial 50 consecutive cases of HINTEGRA total ankle replacement.

Materials And Methods: This was a retrospective study of 50 cases composed of 30 men and 18 women of average age 57 years. Perioperative complications were used to compare the first 25 cases (Group A) with the subsequent 25 (Group B).

Outcome of achilles tendon ruptures treated by a limited open technique.

Background: The optimal surgical management of Achilles tendon ruptures remains a topic of active debate. Recently, many authors have preferred the limited open method because it afforded sufficient visualization to ensure anatomic apposition of disrupted tendon fibers, minimized local blood supply disturbances, guaranteed free tendon movement, and produced excellent cosmesis. We report our initial experience with this technique and review the literature.

Two-stage reconstruction of infected hip joints.

Two-stage reconstruction using an antibiotic-loaded cement spacer is the preferred treatment of deep infection after total hip arthroplasty (THA). We evaluated the results of this technique for the treatment of primary hip infections. Nine consecutive patients with infected hip joints were treated using this technique.

Modified transtrochanteric rotational osteotomy for femoral head osteonecrosis.

Osteonecrosis of the femoral head is a disabling condition affecting young patients and treatment of the disease in these patients is variable. We retrospectively reviewed 39 patients (43 hips) in whom a modified transtrochanteric rotational osteotomy was performed for osteonecrosis. The minimum followup was 24 months (mean, 36.

Serum ion level after metal-on-metal THA in patients with renal failure.

We retrospectively reviewed cementless THAs with metal-on-metal bearings in five patients with chronic renal failure and investigated the relations between renal failure and elevated serum cobalt and chromium levels and the side effects of these elevations. Serum cobalt and chromium levels were measured by atomic absorption spectrophotometry at a minimum followup of 2.7 years (mean, 3.

Comparative study of stability after total knee arthroplasties between navigation system and conventional techniques.

The aim of this study was to evaluate the stability of mediolateral laxity in extension and anteroposterior laxity in 90 degrees of flexion using stress radiographs, modified Hospital for Special Surgery scores, and range of motion of total knee arthroplasties (TKAs) performed using a navigation system (navigation-assisted group, 42 knees) after a minimum 1-year follow-up and to compare them with those of a conventional TKA (conventional group, 44 knees) using a gap technique. The mean medial laxities were 3.5 degrees in the navigation-assisted group and 4.

Functional results of navigated minimally invasive and conventional total knee arthroplasty: a comparison in bilateral cases.

This prospective study aimed to compare the clinical and radiologic results achieved using navigation-assisted minimally invasive surgery (NA-MIS) and conventional techniques in 42 patients who underwent bilateral total knee arthroplasty (TKA), with a minimum 1-year follow-up. Patients who underwent NA-MIS TKA showed better Hospital for Special Surgery (HSS) Scores and Western Ontario MacMaster (WOMAC) total scores for up to 6 months postoperatively than patients who underwent conventional TKA, and lower WOMAC pain score for up to 9 months postoperatively. Range of motion (ROM) was comparable in both groups at all times.

Fifteen- to 20-year results of uncemented tapered fully porous-coated cobalt-chrome stems.

In this paper, we evaluated the long-term results of uncemented total hip arthroplasties using tapered fully porous-coated cobalt-chrome stems (Autophor 900S). The average follow-up was 206 months in 127 hips (113 patients). The articulations of the joints were ceramic-on-polyethylene in 43 hips and ceramic-on-ceramic in 84.

Kinematic study following double-bundle, anterior cruciate ligament reconstruction.

The purpose of this study was to evaluate tibiofemoral kinematics after double-bundle anterior cruciate ligament (ACL) reconstructions and compare them with those of successful single-bundle reconstructions and contralateral normal knees using open MR images. We obtained MR images based on the flexion angle without weight-bearing, from 20 patients with successful unilateral single-bundle (10 patients) and double-bundle (10 patients) ACL reconstructions with tibialis anterior allografts and a minimum 1-year follow-up. The MR images of the contralateral uninjured knees were used as normal controls.

Tibial plateau stress fracture after unicondylar knee arthroplasty using a navigation system: two case reports.

Satisfactory alignments of components in total knee arthroplasty have been reported since the introduction of navigation systems. And thus, such techniques have been introduced for minimally invasive unicondylar knee arthroplasty (UKA). Several intraoperative fractures of the tibial plateau have been reported in association with minimally invasive UKA and some stress fractures of tibial plateau associated with design of instrument have been reported.

In vivo stability of total knee arthroplasty using a navigation system.

The aim of this study was to evaluate in vivo stability for mediolateral laxity in extension and anteroposterior laxity in 90 degrees of flexion and to correlate these and the range of motion (ROM) in 42 total knee arthroplasties (TKA) performed using a navigation system, with a minimum 1-year follow-up. The following parameters were measured at the final follow-up: mediolateral laxity in extension and anteroposterior laxity in 90 degrees of flexion as determined by stress radiographs and a Telos arthrometer, modified HSS scores (excluding laxity and range of motion) and the range of motion (ROM). The mean modified HSS score was 82% of 82 maximum allowable points, and the mean postoperative ROM was 128.