Publications by authors named "Sang Guk Lee"
Objective: This study aimed to evaluate the effectiveness and safety of everolimus in treating seizures associated with focal cortical dysplasia type 2 (FCD 2).
Methods: A prospective, crossover, placebo-controlled clinical trial (ClinicalTrials.gov: NCT03198949) enrolled patients aged 4-40 years with pathologically confirmed FCD 2 and a history of ≥3 seizures per month for two out of the 3 months prior to screening.
Article Synopsis
- * Current imaging methods for detecting these kidney problems are not efficient for quick screening, making early detection difficult.
- * A study conducted on blood samples from TSC patients discovered 7 key chemical markers, including octanoic acid, that could predict kidney AML/cysts, indicating potential new diagnostic approaches for monitoring these conditions.
This study investigates the applicability of six transition metal dichalcogenides to efficient therapeutic drug monitoring of ten antiepileptic drugs using laser desorption/ionization-mass spectrometry. We found that molybdenum ditelluride and tungsten ditelluride are suitable for the sensitive quantification of therapeutic drugs. The contribution of tellurium to the enhanced efficiency of laser desorption ionization was validated through theoretical calculations utilizing an integrated model that incorporates transition-metal dichalcogenides and antiepileptic drugs.
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- * A clinical trial was conducted to gather data on everolimus from September 2017 to May 2020 at a Korean hospital, leading to the development of a population pharmacokinetic model using specialized software.
- * The model suggested that different doses of everolimus are needed based on the patient's body surface area (BSA), with recommendations including higher doses for patients with lower BSA and a sufficient dose of 4.5 mg/m for those with a larger BSA to achieve the desired
Alanine to glycine ratio is a novel predictive biomarker for type 2 diabetes mellitus.
Diabetes Obes Metab
March 2024
Article Synopsis
- The study aimed to identify metabolite ratios that could predict the occurrence or remission of type 2 diabetes mellitus (T2D).
- Researchers analyzed data from 1,813 participants without T2D and 451 newly diagnosed cases to test these metabolites' predictive power using statistical models.
- Findings revealed that a high alanine/glycine ratio significantly predicts T2D incidence, while hydroxy sphingomyelin C22:2 is linked to remission; combining these ratios with obesity levels further assesses diabetes risk.
Article Synopsis
- This study aimed to create a pharmacokinetic model for methotrexate specifically for Korean patients with blood cancers and suggest personalized dosing strategies.
- Researchers analyzed data from 188 patients over a decade, identifying key factors like age and kidney function that affect drug clearance and distribution.
- The final two-compartment model produced tailored dosing recommendations that can help optimize treatment outcomes for this patient group.
Article Synopsis
- Vancomycin, a common antibiotic, can lead to ototoxicity and nephrotoxicity, especially when overprescribed; this study focuses on optimizing its dosage to minimize these risks.
- Researchers created a population pharmacokinetic (PK) and pharmacodynamic (PD) model using data from 542 patients, revealing factors influencing vancomycin clearance and distribution.
- Simulations showed that using model-informed dosing can keep drug concentrations within safe limits, and a new R Shiny application visualizes this data for easier treatment design.
Background: Carbohydrate antigen (CA) 19-9 is a known pancreatic cancer (PC) biomarker, but is not commonly used for general screening due to its low sensitivity and specificity. This study aimed to develop a serum metabolites-based diagnostic calculator for detecting PC with high accuracy.
Methods: A targeted quantitative approach of direct flow injection-tandem mass spectrometry combined with liquid chromatography-tandem mass spectrometry was employed for metabolomic analysis of serum samples using an Absolute IDQ™ p180 kit.
Article Synopsis
- The study compares two assays for measuring free light chains (FLC) in serum—Freelite with the SPAplus analyzer and N Latex FLC with the Atellica CH 930 analyzer—focusing on their diagnostic effectiveness for plasma cell disorders, particularly multiple myeloma.
- A total of 322 serum samples were collected from 193 patients, and while the N Latex FLC assay showed good precision and reliability for routine use, significant discrepancies (up to 170% bias) arose in high-concentration samples, particularly for lambda light chains.
- The findings highlight the importance of consistency in assay selection for monitoring disease status in multiple myeloma, as changing platforms can lead
Purpose: Acute kidney injury (AKI) following sepsis is associated with higher mortality; however, reliable biomarkers for AKI development and recovery remain to be elucidated.
Materials And Methods: Patients with sepsis admitted to the medical intensive care unit (ICU) of Severance Hospital between June 2018 and May 2019 were prospectively analyzed. Patients were divided into those with and without AKI within 48 hours.
Background: Despite the superiority of non-HDL cholesterol (non-HDL-C) and apolipoprotein B (ApoB) as lipid markers for atherosclerotic cardiovascular disease (ASCVD), these are only suitable as secondary markers. We compared LDL cholesterol (LDL-C), non-HDL-C, and ApoB concentrations with respect to the occurrence of cardiovascular disease in adults enrolled in the Korean Genome and Epidemiology Study (KoGES).
Methods: We used information on age; sex; medical history; family history of ASCVD; current lipid-lowering therapy; current smoking status; and creatinine, total cholesterol, HDL-C, LDL-C, triglyceride, and ApoB concentrations from 5,872 KoGES participants without ASCVD.
Article Synopsis
- Apolipoprotein monitoring is important for diagnosing cardiovascular diseases, which are associated with arteriosclerosis, but current methods struggle with sample preparation accuracy and efficiency in clinical settings.
- This research developed a simplified simultaneous assay for key apolipoproteins using a high-throughput LC-MS/MS platform, reducing preparation time and maintaining accurate quantification without complex steps.
- The assay showed strong validation results over 41 days with over 100 human serum samples, demonstrating good correlation with existing methods, and is flexible for future expansion to include other proteins or isoforms.
Background: We aimed to suggest muscle mass-based criteria for using of the cystatin C test for the accurate estimated glomerular filtration rate (eGFR).
Materials And Methods: We recruited 138 Korean subjects and evaluated eGFRcr (derived from Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) based on creatinine) was compared to eGFRcys based on cystatin C as the reference value. The skeletal muscle mass index (SMI) by bioelectrical impedance analysis (BIA) was used as representative of muscle mass.
Article Synopsis
- NT-proBNP is a key biomarker used to diagnose heart failure, and the study compares three different immunoassays: Atellica IM, Alere, and Elecsys proBNP II.
- The analytical performance of the Atellica IM assay was found acceptable, with a slight bias compared to Elecsys proBNP II, but all assays showed good agreement in results.
- While all three assays performed similarly overall, the Elecsys proBNP II assay demonstrated better specificity and likelihood ratios for diagnosing heart failure.
Background: Accurate measurement of glycated hemoglobin (HbA1c) is crucial for a diabetes diagnosis and subsequent patient management. The detection method and presence of variant Hb can interfere with HbA1c measurements. We evaluated the HbA1c-measuring performance of the DxC 700 AU (Beckman Coulter, Brea, CA, USA) immunoassay-based device in comparison with another immunoassay device and the reference method.
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- * A study involving 63 NAFLD patients explored how different treatments impacted metabolomic changes and identified specific metabolites linked to treatment responses after 12 weeks.
- * The research indicated that certain metabolic changes could effectively predict improvements in liver fat and stiffness, enhancing our understanding of the physiological effects of medications used for NAFLD.
Unlabelled: A ketogenic diet (KD) is known to have beneficial health effects. Various types of KD interventions have been applied to manage metabolic syndrome based on modification of diet parameters such as duration of intervention, macronutrient components, and total calories. Nevertheless, the beneficial health impact of isocaloric KD is largely unknown, especially in healthy subjects.
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- Pediatric cancer patients on chemotherapy or radiation often need central venous catheters (CVCs) for blood draws, but using serum from CVCs can lead to issues in routine chemistry tests due to clotting problems.
- A study analyzed blood samples from 52 pediatric oncology patients using both serum separating tubes (SSTs) and lithium heparin tubes (LHTs) to compare biochemical analyte results.
- Results indicated that while most analytes showed acceptable bias, specific measurements for albumin, potassium, inorganic phosphorus, and total protein required careful interpretation due to constant biases identified when comparing serum and plasma results.
Intracellular accumulation of mutant proteins causes proteinopathies, which lack targeted therapies. Autosomal dominant hearing loss (DFNA67) is caused by frameshift mutations in . Here, we show that DFNA67 is a toxic proteinopathy.
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- Vancomycin therapy targets have been established for methicillin-resistant Staphylococcus aureus but not for other gram-positive infections, prompting research into its efficacy for enterococcal bacteremia.
- In a study involving 37 patients treated with vancomycin, a trough level of 15 µg/mL or lower was linked to a higher 28-day mortality rate (21.6%).
- The findings suggest that low vancomycin concentrations and younger age may influence mortality outcomes, indicating a need for larger studies to further explore these pharmacokinetic-pharmacodynamic relationships.
Article Synopsis
- Obesity is a major risk factor for type 2 diabetes, but not all obese individuals develop the disease; this study aimed to investigate how certain metabolites are linked to diabetes in obese people using a large cohort study.
- Researchers analyzed 12 years of metabolomic data from 2,580 participants, focusing on 704 obese individuals who later developed type 2 diabetes while adjusting for traditional risk factors.
- Key metabolites, such as spermine and specific phosphatidylcholines, were found to be significantly associated with the onset of type 2 diabetes, suggesting they could serve as important biomarkers for identifying metabolically healthy obesity and diabetes risk.
Background: Total laboratory automation (TLA) is an innovation in laboratory technology; however, the high up-front costs restrict its widespread adoption. To examine whether the capital investment for TLA is worthwhile, we analyzed its clinical- and cost-effectiveness for the expected payback period.
Methods: Clinical chemistry tests and immunoassays performed in the clinical laboratory of a tertiary care hospital were divided into a post-TLA group, including 1,182,419 tests performed during December 2019, and a pre-TLA group, including 1,151,501 tests performed during December 2018.
Article Synopsis
- Sepsis, a serious medical condition, currently lacks effective biomarkers for diagnosis, prompting the development of a new sepsis biomarker based on serum amino acid profiling.
- Researchers analyzed blood samples from multiple groups to identify amino acids that could distinguish sepsis from other inflammatory conditions using mass spectrometry.
- The study identified key amino acids and created a multivariate formula that performs comparably to existing biomarkers like procalcitonin, suggesting its potential for use in clinical settings.
Article Synopsis
- * The study introduces a new method using laser desorption ionization mass spectrometry (LDI-MS) combined with tungsten disulfide nanosheets, which improves sensitivity and reproducibility for drug monitoring.
- * This innovative approach enables high-throughput analysis of blood samples, successfully tested on 80 patient cases, showing promise to replace existing methods and improve drug management for organ transplant patients.
Background: We established age-group-specific reference intervals for serum anti-Müllerian hormone (AMH) levels in a Korean population and investigated the effectiveness of AMH assay for polycystic ovary syndrome (PCOS) diagnosis.
Methods: We analyzed serum levels of AMH, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) from 1540 Korean women. Subjects were divided into three groups: healthy, benign gynecologic diseases, and PCOS.