Insights into hepatocellular adenomas in Asia: molecular subtypes, clinical characteristics, imaging features, and hepatocellular carcinoma risks.

Hepatocellular adenomas (HCAs) are benign monoclonal liver tumors. Advances in molecular studies have led to the identification of distinct subtypes of HCA with unique pathways, clinical characteristics, and complication risks, underscoring the need for precise diagnosis and tailored management. Malignant transformation and bleeding remain significant concerns.

Whole-brain BOLD responses to graded hypoxic challenges at 7 T, 9.4 T, and 15.2 T: Implications for ultrahigh-field functional MRI and BOLD-dynamic susceptibility contrast MRI.

Purpose: Blood oxygen-level dependent (BOLD) functional MRI signals depend on changes in deoxyhemoglobin content, which is associated with baseline cerebral blood volume (CBV) and blood oxygen saturation change. To accurately interpret activation-induced BOLD responses and quantify perfusion values by BOLD dynamic susceptibility contrast (BOLD-DSC) with transient hypoxia, it is critical to assess Δ values in tissue and blood across varying levels of hypoxia and magnetic field strengths (B).

Methods: Whole-brain BOLD responses were examined using 5-s graded hypoxic challenges with 10%, 5%, and 0% O at ultrahigh field strengths of 7 T, 9.

Biomedical Signal Processing and Health Monitoring Based on Sensors.

The healthcare industry is undergoing rapid transformation driven by advancements in Internet of Things (IoT) technologies, particularly in biomedical signal processing and health monitoring [...

Preoperative Prediction Model for Early Recurrence of Intrahepatic Cholangiocarcinoma After Surgical Resection: Development and External Validation Study.

Purpose: We aimed to develop a preoperative risk scoring system to predict early recurrence (ER) of intrahepatic cholangiocarcinoma (ICCA) after resection, utilizing clinical and computed tomography (CT) features.

Materials And Methods: This multicenter study included 365 patients who underwent curative-intent surgical resection for ICCA at six institutions between 2009 and 2016. Of these, 264 patients from one institution constituted the development cohort, while 101 patients from the other institutions constituted the external validation cohort.

Effect of combining serum alpha-fetoprotein with LI-RADS v2018 on gadoxetate-enhanced MRI in the diagnosis and prognostication of hepatocellular carcinoma.

Objectives: To evaluate the performance of combining serum alpha-fetoprotein (AFP) with LI-RADS (LI-RADS + AFP) on gadoxetate-enhanced MRI for diagnosing hepatocellular carcinoma (HCC) ≤ 3.0 cm and predicting post-surgical patient outcomes, compared to LI-RADS v2018.

Methods: Patients with hepatic observations ≤ 3.

Clinical Outcome and Utility of Cone‑Beam Computed Tomography Imaging for Transcatheter Arterial Embolization in Patients with Malignant Intractable Hematuria.

We assess the clinical outcomes and utility of cone‑beam computed tomography (CBCT) during transcatheter arterial embolization (TAE) in patients with malignant intractable hematuria, related to lower urinary tract malignancy. A total of 22 consecutive patients (20 males and 2 females; age 71.8 ± 9.

Preventive role of Pastinaca sativa in mitigating metabolic dysfunction-associated steatotic liver disease via modulation of metabolic endotoxemia.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading global liver disorder. Parsnip (Pastinaca sativa), rich in dietary fiber and medicinal properties, has shown health benefits, but its effects on MASLD are largely unexplored. This study evaluated the prebiotic and anti-MASLD effects of parsnip root water-soluble extract (PRE) in a mouse model.

Non-equilibrium spin dynamics of the frustrated trication spinel ZnMnCoOin the hierarchical free-energy framework.

Short-range spin correlations, memory and rejuvenation effects have been reported in the trication oxispinel ZnMnCoOwhose low-temperature spin dynamics, triggered by magnetic frustration (fr∼6), could be better explained by the 'phenomenological' hierarchical free-energy model than the short-range droplet theory. Accordingly, the aging mechanism of the system had an asymmetric memory response to the positive and negative thermal cycles within the cluster-glass state (T<32.6 K) and demonstrated a hierarchical organization of the phase space where its metastable energy states undergo continuous splitting with decreasing temperature.

Prebiotic Activity of Rhizome Extract and Its Effects on Obesity and Gut Inflammation.

(sweet flag), a medicinal plant, especially its rhizome, shows strong antioxidant and anti-inflammatory effects; however, its efficacy in treating intestinal inflammation and obesity is still unexplored. In this study, we investigated the prebiotic activity of sweet flag rhizome extract (SRE) and its preventive effects against high-fat diet (HFD)-induced obesity and colonic inflammation. The prebiotic activity was assessed based on the prebiotic activity scores of four probiotic strains.

Evaluation of a modified formalism for precision electron beam dosimetry compared to TG-51 and TRS-398.

Purpose: This study aims to evaluate a modified formalism for electron beam reference dosimetry and to compare the results with the cases of previous protocols TG-51 and TRS-398.

Methods: Measurements were performed using three types of cylindrical chambers (TW30013, FC65-G, and A1SL) and plane-parallel chambers (PPC) (Roos, Advanced Markus, and NACP-02) with electron beams of energies 6, 12, and 18 MeV. Absorbed dose to water at the reference depths was determined following the modified formalism using different chambers and methods, including the direct application of Co calibration or cross-calibration for PPCs in a high-energy electron beam.

Feasibility of rabbit auricular VX2 tumor model as an experimental model for intra-arterial embolization.

This study aimed to evaluate the feasibility of VX2 tumor in rabbit auricles as an experimental model for intra-arterial embolization. This study was approved by our Institutional Animal Care and Use Committee. VX2 tumors were implanted in both auricles of 12 New Zealand White Rabbits.

LI-RADS Ultrasound Surveillance Version 2024: Comparison With Version 2017 for Hepatocellular Carcinoma Detection and Risk Factors for Visualization Score C.

The LI-RADS Ultrasound Surveillance algorithm was updated in 2024, incorporating alpha-fetoprotein (AFP) and visualization score of VIS-C into management recommendations after nonpositive results. This study aimed to compare the diagnostic performance of LI-RADS Ultrasound Surveillance version 2017 (v2017) and version 2024 (v2024) for hepatocellular carcinoma (HCC) detection in at-risk patients and to identify predictors of VIS-C on follow-up surveillance examinations. This retrospective analysis included 407 patients (median age, 56 years; 230 male, 177 female) with cirrhosis who underwent rounds of semi-annual surveillance ultrasound as part of a prospective trial from November 2011 to December 2012.

The mitochondrial genome of H. Lév. & Vaniot, an endemic sedge in Korea.

H. Lév. & Vaniot is an endemic species in Korea and is included in the clade of section in the recent classification system.

Clinical Outcomes of Total or Partial Renal Artery Embolization in Patients with Spontaneous Renal Bleeding.

Aims: The aim of this study was to evaluate renal artery embolization in patients with spontaneous renal artery bleeding based on detailed angiographic findings and a comprehensive analysis of its efficacy and clinical outcomes.

Materials And Methods: This retrospective study evaluated the outcomes of renal artery embolization in 18 cases among 15 patients (11 men and 4 women; mean age: 57.9 years) treated for spontaneous renal bleeding at our institution between March 2017 and October 2023.

Effect of nanoparticulate CaCO on the biological properties of calcium silicate cement.

This study aimed to evaluate the effects of nanoparticulate CaCO (NPCC) on the biological properties of calcium silicate-based cements (CSCs), including their cytotoxicity, in vitro osteogenic activity, and interactions with rat femur tissue. The average size of NPCC was 90.3±26.

CT- and MRI-based Factors Associated with Rapid Growth in Early-Stage Hepatocellular Carcinoma.

Background Prediction of the tumor growth rates is clinically important in patients with hepatocellular carcinoma (HCC), but previous studies have presented conflicting results and generally lacked radiologic evaluations. Purpose To evaluate the percentage of rapidly growing early-stage HCCs in each Liver Imaging Reporting and Data System (LI-RADS) category and to identify prognostic factors associated with rapid growth. Materials and Methods Retrospective study of patients with risk factors for HCC and those with surgically proven early-stage HCC who underwent two or more preoperative multiphasic CT or MRI examinations between January 2016 and December 2020.

Genome-wide phenotypic profiling of transcription factors and identification of novel targets to control the virulence of Vibrio vulnificus.

For successful infection, the life-threatening pathogen Vibrio vulnificus elaborately regulates the expression of survival and virulence genes using various transcription factors (TFs). In this study, a library of the V. vulnificus mutants carrying specific signature tags in 285 TF genes was constructed and subjected to 16 phenotypic analyses.

LI-RADS Category Can Be a Post-Surgical Prognostic Factor for Intrahepatic Cholangiocarcinoma in Patients with Liver Cirrhosis or Chronic Hepatitis B.

Introduction: The Liver Imaging Reporting and Data System (LI-RADS) categorization has been proposed as a potential prognostic indicator for primary liver neoplasms in patients with liver cirrhosis or chronic hepatitis B. This multicenter study aimed to determine whether LI-RADS categorization can offer additional post-surgical prognostic value for intrahepatic cholangiocarcinoma (ICCA) when used in conjunction with the American Joint Committee on Cancer (AJCC) guidelines.

Methods: Patients with high risk for hepatocellular carcinoma, surgically confirmed ICCAs, and available preoperative MRI were enrolled.

Clinical Outcomes of Transcatheter Arterial Embolization in Patients with High-grade Gross Hematuria.

Introduction: To investigate factors influencing the effectiveness and safety of super-selective embolization in patients with high-grade gross hematuria.

Materials And Methods: This retrospective, single-center study included 19 consecutive cancer patients (12 men and 7 women, mean age of 72.3 years) who had undergone TAE for intractable hematuria between January 2008 and February 2024.

LI-RADS: Current Status and Future Directions.

The Liver Imaging Reporting and Data System (LI-RADS) is a comprehensive system that uses standardized terminology, technique, interpretation, and reporting of imaging studies for hepatocellular carcinoma surveillance, diagnosis, and locoregional treatment response assessment. Since its initial release in 2011, LI-RADS has evolved and expanded in scope. In this article, we discuss recent updates intended to address clinical needs and mitigate current challenges.

Risk of Contrast-Induced Acute Kidney Injury in Computed Tomography: A 16 Institutional Retrospective Cohort Study.

Objectives: Concern about contrast-induced acute kidney injury (CI-AKI) may delay the timely administration of contrast media for computed tomography (CT). The precise causative effect of iodinated contrast media on CI-AKI and its relevant risk factors remains an area of ongoing investigation. Therefore, this study aimed to determine the risk of CI-AKI following contrast-enhanced CT and its predisposing risk factors.

Grifola frondosa extract as a fetal bovine serum supplement for the culture of bovine muscle satellite cells under low serum conditions.

Expensive fetal bovine serum (FBS) is a major obstacle to the production of cultivated meat. However, because FBS substitutes do not sufficiently induce cell proliferation, a good alternative is to reduce the amount of FBS and use ingestible additives to promote cell proliferation. In this study, Grifola frondosa extract (GFE) was used to investigate its potential as an additive to promote myogenesis of bovine muscle satellite cells from Hanwoo cattle under low serum conditions (10 % FBS).

ChIP-seq and structural analyses delineating the regulatory mechanism of master regulator EsrB in .

Unlabelled: As a response regulator of the EsrA-EsrB two-component system, EsrB is conserved in and plays a crucial role in virulence and pathogenicity. EsrB possesses DNA binding abilities, enabling it to regulate the transcription of virulence genes to confront different stresses and achieve systematic infections. Here, ChIP-seq analysis of EsrB in Dulbecco's Modified Eagle's Medium (DMEM) (mimicking environments) revealed that EsrB preferred to bind to virulence-associated promoters with a distinct 7'-4-7'' pseudopalindromic DNA motif and interact with metabolic-related promoters with a high AT DNA motif.

A Multicenter Study on Hepatocellular Adenomas in Korea: Clinicopathological and Imaging Features With an Emphasis on β-Catenin Mutated Subtype.

Background & Aims: The clinicopathologic and imaging features of hepatocellular adenomas (HCAs) in Asian population remain unclear. We aimed to analyse clinicopathologic and imaging features of HCAs in Korea and propose an imaging-based method to differentiate β-catenin mutated HCA (βHCA) from other subtypes.

Methods: This retrospective multicenter study included pathologically confirmed HCAs from three tertiary institutions in Korea between 2010 and 2023.