Publications by authors named "Sang Ah Chi"
Background/aim: Invasive stratified mucin-producing carcinoma (ISMC) is a rare but aggressive variant of endocervical adenocarcinoma (EAC). The aim of this study was to investigate the differences in clinicopathological features, patient outcomes, and programmed death-ligand 1 (PD-L1) expression among ISMC, usual-type EAC (UEA), and gastric-type EAC (GEA).
Patients And Methods: PD-L1 22C3 immunostaining was performed using 20 ISMCs, 20 UEAs, and 20 GEAs.
Background: Surgery is the primary treatment for non-small cell lung cancer (NSCLC), but microscopic residual disease may be unavoidable. Preclinical studies have shown that volatile anesthetics might suppress host immunity and promote a pro-malignant environment that supports cancer cell proliferation, migration, and angiogenesis, whereas propofol may preserve cell-mediated immunity and inhibit tumor angiogenesis. However, clinical evidence that propofol-based total intravenous anesthesia (TIVA) can reduce tumor recurrence after curative resection remains inconsistent due to the retrospective observational nature of previous studies.
View Article and Find Full Text PDFObjectives: To investigate whether ultrafast sequence improves the diagnostic performance of conventional dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in differentiating additional suspicious lesions (ASLs) on preoperative breast MRI.
Materials And Methods: A retrospective database search identified 668 consecutive patients who underwent preoperative breast DCE-MRI with ultrafast sequence between June 2020 and July 2021. Among these, 107 ASLs from 98 patients with breast cancer (36 multifocal, 42 multicentric, and 29 contralateral) were identified.
Article Synopsis
- Dysphonia, which is a voice disorder, impacts social interaction and overall quality of life, and the study sought to explore how dietary and habitual factors relate to this condition using data from the Korean National Health and Nutritional Examination Survey.
- The research involved a large group of adults who underwent exams for dysphonia and provided information about their diets and habits, identifying risk factors for both dysphonia and laryngeal mucosal diseases.
- Findings revealed that age, body weight, and female sex were key factors associated with dysphonia, while smoking and niacin intake were significant for laryngeal mucosal diseases; diet-related factors like specific nutrient intakes did not show strong correlations.
Introduction: The long-term effects of fenestration in patients with Fontan circulation remain unclear. We aim to evaluate the fenestration impact on early and late outcomes in patients with extracardiac Fontan (ECF) using a propensity score matching analysis.
Methods: We performed an extensive retrospective multicenter clinical data review of the Korean Fontan registry and included 1,233 patients with surgical ECF (779 fenestrated, 454 non-fenestrated).
Article Synopsis
- - The study analyzed the relationship between herpes simplex virus (HSV) and varicella zoster virus (VZV) infections and the risk of developing dementia in over 750,000 individuals aged 45 and older in South Korea from 2006 to 2017.
- - Findings indicated that both HSV and VZV infections significantly increased dementia risk, with co-infection leading to the highest risk and a quicker onset of dementia symptoms (average 4.09 years after infection).
- - The research also highlighted that all categories of HSV and VZV infections correlated with elevated dementia risk, affecting various types of dementia, including Alzheimer's disease and vascular dementia.
Background: The objective of this study was to evaluate the efficacy and safety of totally thoracoscopic ablation (TTA) in patients with recurrent atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA).
Methods: From February 2012 to May 2020, 460 patients who underwent TTA were classified into two groups: CA (presence of RFCA history, n = 74) and nCA groups (absence of RFCA history, n = 386). Inverse probability of treatment weighting (IPTW) analyses were used to adjust for confounders.
Article Synopsis
- Over the last decade, the treatment landscape for non-small cell lung cancer (NSCLC) has evolved significantly, but traditional clinical trials may not quickly capture the real-world outcomes of these advancements.
- This study aimed to analyze the outcomes of new NSCLC treatments by comparing survival rates and other variables from two time periods (2010-2015 and 2016-2020) in patients treated at Samsung Medical Center in Korea.
- The results revealed increased testing for molecular variations in adenocarcinoma patients and showed improved survival rates in the later period, indicating potential benefits from new therapies and testing protocols.
Background In patients with hepatocellular carcinoma (HCC) who undergo follow-up with CT after treatment, the benefit of routinely including pelvic coverage is not well substantiated. Purpose To investigate the added value of pelvic coverage at follow-up liver CT in detecting pelvic metastasis or incidental tumors in patients treated for HCC. Materials and Methods This retrospective study included patients who were diagnosed with HCC between January 2016 and December 2017 and followed up with liver CT after treatment.
View Article and Find Full Text PDFBackground: With collection of repeated 24-hour recalls, there exist challenges in usual intake estimation, including infeasibility of multiple dietary assessments, and shortage of non-zero intakes for episodically consumed foods.
Objectives: We developed an ensemble method based on marginal-effect models (EMM), which estimates usual intake distribution using single-day data with internal or external two-day data.
Methods: The performance of the EMM was evaluated and compared with the National Cancer Institute (NCI) method and NCI 1-d method, via simulations with various scenarios and real data analyses of red meat, fish, and protein from Korea National Health and Nutrition Examination Survey (KNHANES).
Background: The current standard treatment for limited-stage small-cell lung cancer (LS-SCLC) is chemotherapy with concurrent chemoradiotherapy (CCRT).
Methods: In this single-arm phase II study, patients with LS-SCLC received four cycles of etoposide, cisplatin, and durvalumab every 3 weeks. Thoracic radiotherapy of 52.
Background: The current standard treatment for patients with inoperable, locally advanced esophageal squamous cell carcinoma (ESCC) is definitive concurrent chemoradiotherapy (CCRT).
Methods: Patients with locally advanced ESCC received 2 cycles of 5-fluorouracil, cisplatin, durvalumab, and tremelimumab every 3 weeks with concurrent radiation therapy (60.2 or 64.
Background: We investigate the incidence and characteristics of IOL dislocation among the pseudophakic population after phacoemulsification.
Methods: National data were collected from the health claims recorded with the Health Insurance Review and Assessment Service of South Korea from 2009 to 2016. Pseudophakic patients aged 40 years or older were included.
We investigated the effect of visual impairment (VI) on dementia development in a national cohort. In this 12-year nationwide population-based retrospective cohort study, national data were collected from National Health Insurance Cooperation of South Korea from 2002 to 2017, comprising 799,074 subjects selected from the dementia-free cohort representative of the Korean population. Crude hazard ratios (HRs) as well as age- and sex-adjusted HRs and confidence intervals (CIs) for the development of dementia were estimated using multivariable Cox regression models.
View Article and Find Full Text PDFPurpose: Few studies have measured the incidence and risk factors of intraocular lens (IOL) dislocation in the total population. We investigate the risk factors for IOL dislocation in a nationwide Korean cohort.
Design: Retrospective cohort study.
In this paper, we investigate K-group comparisons on survival endpoints for observational studies. In clinical databases for observational studies, treatment for patients are chosen with probabilities varying depending on their baseline characteristics. This often results in noncomparable treatment groups because of imbalance in baseline characteristics of patients among treatment groups.
View Article and Find Full Text PDFPurpose: This study aims to evaluate the treatment outcomes of iodized oil transarterial chemoembolization (TACE) and subsequent radiofrequency ablation (RFA) for small (≤3 cm) periportal hepatocellular carcinoma (HCC) compared with nonperiportal HCC.
Methods: Twenty-three patients [periportal group (PG); mean age, 59.8 years; 22 men, 1 woman] with periportal HCC (in contact with the portal vein >3 mm in diameter) and 279 patients [nonperiportal group (NPG); mean age, 59.
Goal: To provide the statistical predictive model for neoplastic potential of gallbladder polyp (GBP).
Background: Many studies have attempted to define the risk factors for neoplastic potential of GBP. It remains difficult to precisely adapt the reported risk factors for the decision of surgery.
Article Synopsis
- * Out of the patients, 3% experienced structural recurrences, with younger patients more likely to have lymph node recurrences and older patients having local or distant recurrences, indicating differing risk factors based on age and tumor characteristics.
- * Key findings showed that factors such as multifocal tumors and lymph node metastasis increased the risk of lymph node recurrences, while older age and larger tumors correlated with local/distant recurrences; central neck dissection was noted to reduce these risks.