Publications by authors named "Sanel Durakovic"
Article Synopsis
- The study focuses on a particularly resilient strain of non-typeable Haemophilus influenzae (NTHi), identified as NTHi23, which demonstrates strong resistance to human serum due to specific genetic mechanisms.* -
- NTHi23 was found to share complement evasion strategies with other invasive strains, including unique alterations to its lipooligosaccharide (LOS) structure that help it avoid immune attack.* -
- Research revealed that a variant of NTHi23, after undergoing a genetic change in the lpsA gene, became significantly more sensitive to serum killing, implying that the nasopharyngeal environment favors strains with intact serocomplement evasion capabilities.*
Bacterial outer membrane vesicles (OMVs) have important biological roles in pathogenesis and intercellular interactions, but a general mechanism of OMV formation is lacking. Here we show that the VacJ/Yrb ABC (ATP-binding cassette) transport system, a proposed phospholipid transporter, is involved in OMV formation. Deletion or repression of VacJ/Yrb increases OMV production in two distantly related Gram-negative bacteria, Haemophilus influenzae and Vibrio cholerae.
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