Publications by authors named "Sandy Song"
Objectives: Although lower hemoglobin levels associate with worse intracerebral hemorrhage (ICH) outcomes, causal drivers for this relationship remain unclear. We investigated the hypothesis that lower hemoglobin relates to increased hematoma expansion (HE) risk and poor outcomes using human observational data and assessed causal relationships using a translational murine model of anemia and ICH.
Methods: ICH patients with baseline hemoglobin measurements and serial CT neuroimaging enrolled between 2010-2016 to a multicenter, prospective observational cohort study were studied.
Article Synopsis
- Anemia after intracerebral hemorrhage (ICH) worsens clinical outcomes, and inflammation plays a significant role in its development.
- In a study of 42 patients, anemia prevalence rose sharply from 19% to 45% within five days post-ICH, with 88% meeting criteria for inflammation-related anemia.
- A larger group of 521 patients showed anemia prevalence increasing from 30% to 71% in two days, linking higher inflammation scores to greater decreases in hemoglobin, which correlated with worse neurological outcomes at 90 days.