An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants.

The role of non-coding regulatory elements and how they might contribute to tissue type specificity of disease phenotypes is poorly understood. Autosomal Dominant Leukodystrophy (ADLD) is a fatal, adult-onset, neurological disorder that is characterized by extensive CNS demyelination. Most cases of ADLD are caused by tandem genomic duplications involving the lamin B1 gene (LMNB1) while a small subset are caused by genomic deletions upstream of the gene.

An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants.

The role of non-coding regulatory elements and how they might contribute to tissue type specificity of disease phenotypes is poorly understood. Autosomal Dominant Leukodystrophy (ADLD) is a fatal, adult-onset, neurological disorder that is characterized by extensive CNS demyelination. Most cases of ADLD are caused by tandem genomic duplications involving the lamin B1 gene ( ) while a small subset are caused by genomic deletions upstream of the gene.

Evaluation of the MicroWorks, Inc. Swab Sampling System (MSSSTM) for Use in Performing Quantitative Swab Sampling.

The purpose of this study was to qualify the MicroWorks, Inc. Swab Sampling System (MSSS™) swab kit for use in sampling cleanroom surfaces for bioburden. A six-part study was performed to demonstrate the suitability of the swab materials, the recovery of bioburden from typical cleanroom surfaces, the neutralization of typical disinfectants used in cleanrooms, the removal of diluents from the swabbed surface, and the hold time for test samples.