Publications by authors named "Sanduo Li"
Fine particulate matter (PM) is suggested to pose a severe risk to the kidneys by inducing functional degradation and chronic kidney diseases (CKD). This study aims to explore the nephrotoxicity of PM exposure and the underlying mechanism. Herein, based on the UK Biobank, it is found that per interquartile range (IQR) increase in PM is associated with a 6% (95% CI: 1%-11%), 7% (95% CI: 3%-11%), 9% (95% CI: 4%-13%), 11% (95% CI: 9%-13%), and 10% (95% CI: 8%-12%) increase in the risk of nephritis, hydronephrosis, kidney stone, acute renal failure, and CKD, respectively.
View Article and Find Full Text PDFAirborne fine particulate matter (PM) exposure is closely associated with metabolic disturbance, in which brown adipose tissue (BAT) is one of the main contributing organs. However, knowledge of the phenotype and mechanism of PM exposure-impaired BAT is quite limited. In the study, male C57BL/6 mice at three different life phases (young, adult, and middle-aged) were simultaneously exposed to concentrated ambient PM or filtered air for 8 weeks using a whole-body inhalational exposure system.
View Article and Find Full Text PDFIt is well known that extreme heat events happen frequently due to climate change. However, studies examining the direct health impacts of increased temperature and heat waves are lacking. Previous reports revealed that heatstroke induced acute lung injury and pulmonary dysfunction.
View Article and Find Full Text PDFBackground: Previous evidence has identified exposure to fine ambient particulate matter () as a leading risk factor for adverse health outcomes. However, to date, only a few studies have examined the potential association between long-term exposure to and bone homeostasis.
Objective: We sought to examine the relationship between long-term exposure and bone health and explore its potential mechanism.