Publications by authors named "Sandrine Weisse"
Article Synopsis
- A new cholesteryl-cyclodextrin derivative was developed for making nanocapsules, which are tiny carriers for drugs.
- The structure of this derivative, named Chol-betaCD-Ac, was analyzed using advanced NMR technology.
- The nanocapsules successfully encapsulated vitamin A propionate, a poorly soluble drug, enabling stable and consistent size distribution, and facilitating better skin penetration.
We have raised antibodies against two methylated derivatives of beta-CD, heptakis(2,6-di-O-methyl)cyclomaltoheptaose (Dimeb) and heptakis(2,3,6-tri-O-methyl)cyclomaltoheptaose (Trimeb). These antibodies were used to develop two specific and sensitive enzyme immunoassays, presenting a detection limit close to 500 and 30 pg/mL for Trimeb and Dimeb, respectively. Cross reactivities of different linear and cyclic maltooligosaccharides were investigated, demonstrating a high specificity against the structural features of the secondary hydroxyls rim.
View Article and Find Full Text PDFRecently, new cyclodextrin derivatives were synthesized and shown to exhibit strong amphiphilic properties. In this paper, we study the action of these new amphiphilic cyclodextrins on phospholipids. Mixed phospholipid/cyclodextrin derivative films were prepared and studied using X-ray reflectivity for various phospholipid/cyclodextrin ratios.
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