Publications by authors named "Sandrine Joffrion"
Article Synopsis
- Renal ischaemia reperfusion (I/R) leads to oxidative stress, inflammation, and organ failure, with macrophages playing a key role in clearing cell debris through the receptor MerTK.
- This study compared natural MerTK mutant rats (RCS) and wild type rats (WT) to understand MerTK’s impact on kidney damage following I/R induced by clamping renal arteries.
- Findings from various analyses suggest that exploring MerTK's role could enhance our understanding of kidney injury and recovery processes in renal I/R models.
Background: Accumulation of middle-weight uraemic toxins in haemodialysis (HD) patients results in increased morbidity and mortality. Whether medium cut-off HD (MCO-HD) improves removal of middle-weight uraemic toxins remains to be demonstrated.
Methods: This cross-over prospective study included 40 patients randomly assigned to receive either 3 months of MCO-HD followed by 3 months of high-flux HD (HF-HD), or vice versa.
Coagulation is an important pathway in the pathophysiology of ischemia-reperfusion injuries. In particular, deceased after circulatory death (DCD) donors undergo a no-flow period, a strong activator of coagulation. Hence, therapies influencing the coagulation cascade must be developed.
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