Publications by authors named "Sandrine Hugues-Ascery"
Long-term memory formation relies on synaptic plasticity, neuronal activity-dependent gene transcription, and epigenetic modifications. Multiple studies have shown that HDAC inhibitor (HDACi) treatments can enhance individual aspects of these processes and thereby act as putative cognitive enhancers. However, their mode of action is not fully understood.
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- The carotid bodies and baroreceptors are sensors that send information to the brain about physiological conditions and may help in detecting pro-inflammatory cytokine levels, which could trigger an anti-inflammatory response.* -
- In the study, researchers isolated the carotid sinus nerve in mice and applied electrical stimulation before and after administering lipopolysaccharide, and they found that this stimulation reduced inflammation and protected the mice from shock-related death.* -
- The study concluded that the anti-inflammatory effects of carotid sinus nerve stimulation do not rely on the autonomic nervous system but instead involve mechanisms like increased corticosterone production through the hypothalamus and the adrenal glands.*
Vagus nerve stimulation can ameliorate autoimmune diseases such as rheumatoid arthritis by modulation of the immune system. Its efficacy for the treatment of type 1 diabetes has not been explored, in part because the nerves projecting to the pancreatic lymph nodes (pLNs) in mice are unmapped. Here, we map the nerve projecting to the pancreas and pLNs in mice and use a minimally invasive surgical procedure to implant micro-cuff electrodes onto the nerve.
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