Publications by authors named "Sandrine Girerd"
Article Synopsis
- - SOD2 is important for antioxidant defense, and this study investigates its potential link to genetic instability in Chronic Myeloid Leukemia (CML), specifically how silencing SOD2 affects chromosomal stability in cell lines expressing BCR-ABL mutations.
- - Researchers found that SOD2 silencing led to significant genetic instability in specific chromosomal regions and observed lower SOD2 mRNA levels in CML patients, correlating with increased disease severity indicators like leukocytosis and Sokal score.
- - The study suggests that reduced SOD2 expression may contribute to a mutator phenotype in CML patients undergoing Tyrosine Kinase Inhibitor (TKI) therapies, highlighting the need for further research into