Publications by authors named "Sandrine Dunand"
Article Synopsis
- Cell division cycle dual phosphatases (CDC25) regulate cell progression and are over-expressed in various cancers, with three isoforms: CDC25A, B, and C.
- New compounds called 2-(thienothiazolylimino)-1,3-thiazolidin-4-ones were created to inhibit CDC25 phosphatase, and one compound (6) showed a significant inhibitory effect on CDC25A.
- Compound 6 not only inhibited CDC25A in vitro but also caused growth arrest in cancer cell lines MCF7 and MDA-MB-231, marking the first time these 4-thiazolidinone derivatives have been identified as potential CDC25 inhibitors.
A series of 35 heteroarylimino-1,3-thiazolidinones with three sites of functionalization were synthesized and their antiproliferative properties were studied. The in vitro screening by MTT assay was performed against five cancer cell lines (human colon cancer cell lines HT29, HCT116 and SW620 and breast cancer cell lines MCF7 and MDA-MB-231). It was observed that N3-substituted thiazolidinones had moderate activities whereas 5-benzylidene thiazolidinones showed promising activities.
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