Publications by authors named "Sandrine Barakat"
J Control Release
October 2013
Article Synopsis
- Diabetes mellitus (DM) causes metabolic changes that hinder bone repair due to prolonged inflammation, and this study explores the use of a salicylic acid-based polymer to combat that issue.
- The experiment involved creating bone defects in diabetic and normoglycemic rats and treating them with a salicylic acid-polymer/bone graft mixture, assessing bone recovery through imaging and tissue analysis.
- Results showed that diabetic rats treated with the SA-PAE mixture experienced significantly better bone regeneration over time compared to those with only the bone graft, while normoglycemic rats showed initial acceleration in bone formation that leveled off by the 12-week mark.
