Publications by authors named "Sandra T F Tsoi"
Article Synopsis
- Monogenic diabetes results from rare gene mutations affecting beta cell function, and this study examines how common variants may also influence young-onset type 2 diabetes (YOD) and related health issues.
- Researchers created a weighted polygenic risk score (wPRS) using data from individuals with and without YOD to explore the association of 135 common variants across 34 monogenic diabetes genes.
- The findings indicate that higher wPRS correlates with an increased likelihood of YOD and a higher risk for cardiovascular and kidney events in individuals with type 2 diabetes.
Article Synopsis
- A new patient-centered, data-driven care model was developed and implemented to improve clinical outcomes for patients with young-onset type 2 diabetes (T2D), an area lacking well-established practice guidelines.
- The study, part of a 3-year randomized controlled trial, involves a team-based management approach utilizing genetic markers and technology to tailor treatments for individuals diagnosed with T2D before the age of 40.
- Out of 884 participants, those in the specialized JADE-PRISM group received more focused care, showing the potential for better management of complications and treatment goals compared to standard care protocols.
Aims: Asians have a high prevalence of young-onset diabetes, but the pattern of monogenic diabetes is unknown. We aimed to determine the prevalence of monogenic diabetes in Chinese patients with young-onset diabetes and compare the clinical characteristics and outcome between patients with and without monogenic diabetes.
Materials And Methods: We sequenced a targeted panel of 33 genes related to monogenic diabetes in 1021 Chinese patients with non-type 1 diabetes diagnosed at age ≤40 years.
Normal-weight individuals with usual-onset type 2 diabetes have reduced β-cell function and greater insulin sensitivity compared with their obese counterparts. The relative contribution of β-cell dysfunction and insulin resistance to young-onset type 2 diabetes (YOD) among normal-weight individuals is not well established. In 44 individuals with YOD (24 with normal weight and 20 with obesity) and 24 healthy control individuals with normoglycemia (12 with normal weight and 12 with obesity), we conducted 2-h 12 mmol/L hyperglycemic clamps to measure acute (0-10 min) and steady-state (100-120 min) insulin and C-peptide responses, as well as insulin sensitivity index.
View Article and Find Full Text PDFGlucokinase (GK, gene symbol GCK) maturity-onset diabetes of the young (MODY) is caused by heterozygous inactivating mutations in GK and impaired glucose sensing. We investigated effects of dorzagliatin, a novel allosteric GK activator, on insulin secretion rates (ISRs) and β-cell glucose sensitivity (βCGS) in GCK-MODY and recent-onset type 2 diabetes. In a double-blind, randomized, crossover study, 8 participants with GCK-MODY and 10 participants with type 2 diabetes underwent 2-h 12 mmol/L hyperglycemic clamps following a single oral dose of dorzagliatin 75 mg or matched placebo.
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