Publications by authors named "Sandra Sha"
Article Synopsis
- - NIBB (Non-invasive Brachytherapy with Intrabeam) is a promising cancer treatment that offers targeted radiation with less damage to surrounding tissues compared to traditional methods, aiming to reduce treatment sessions from 10 to 5 for efficiency and cost-effectiveness.
- - In a clinical trial with 40 patients having small tumors and negative lymph nodes, the treatment showed excellent 5-year outcomes with 96.6% local control and minimal late toxicity (only 2.5% experienced significant fibrosis), while 75% of patients reported good to excellent cosmetic results.
- - The study concluded that NIBB APBI is effective and safe, with the risk of skin issues like telangiectasia linked to breast
Purpose: The noninvasive image-guided breast brachytherapy (NIBB) technique is a novel noninvasive yet targeted method for accelerated partial breast irradiation. We established a multi-institutional registry to evaluate the toxicity and efficacy of this technique across various practice settings.
Methods And Materials: Institutions using the NIBB technique were invited to participate.
Article Synopsis
- Noninvasive image guided breast brachytherapy (NIBB) is a novel, non-invasive method for delivering accelerated partial breast irradiation (APBI) that uses breast compression and imaging for high precision without large tumor volume margins.* -
- In a phase 2 study involving 40 patients, aged 68 on average, treatment involved delivering a total dose of 34 Gy in 10 fractions, where late toxicity was minimal, with only 5% and 10% reporting grade 2 toxicity at 2 and 5 years, respectively.* -
- Results showed a 95% good to excellent cosmetic outcome at 2 years, a 100% rate at 5 years, and a 93.3%
Purpose: To improve efficiency, convenience, and cost, a prospective phase II trial was initiated to evaluate accelerated partial breast irradiation delivered with noninvasive image-guided breast brachytherapy (NIBB) via five once-daily fractions.
Methods And Materials: Women ≥50 years old with early-stage breast cancer undergoing breast conserving surgery were enrolled. Eligibility criteria included invasive carcinoma ≤2.
Purpose: To report updated feasibility and reproducibility results for high-dose-rate noninvasive breast brachytherapy (NIBB) for tumor bed boost with whole breast radiation therapy (WBRT) in the setting of expanded patient and treatment facility number.
Methods And Materials: Fifteen independent community-based and academic centers reported 518 early-stage breast cancer patients from July 2007 to February 2015 on a privacy-encrypted online data registry. All patients' treatment included lumpectomy followed by combination of WBRT and NIBB.
Purpose: Noninvasive image-guided breast brachytherapy (NIBB) is a novel approach to deliver accelerated partial breast irradiation (APBI). NIBB is noninvasive, yet maintains a high degree of precision by using breast immobilization and image guidance. This makes NIBB an attractive alternative to existing APBI techniques.
View Article and Find Full Text PDFPurpose: To evaluate the feasibility, implementation, and early results of noninvasive breast brachytherapy (NIBB) for tumor bed boost with whole breast radiation therapy (WBRT).
Methods And Materials: NIBB is a commercially available (AccuBoost, Billerica, MA) mammography-based, brachytherapy system in which the treatment applicators are centered on the planning target volume (PTV) to direct (192)Ir emissions along orthogonal axes. A privacy-encrypted online data registry collected information from 8 independent academic and community-based institutions.