Publications by authors named "Sandra Sayuri Nakamura de Vasconcelos"
Article Synopsis
- Piperine, derived from Piper nigrum and Piper longum, has potential as an efflux pump inhibitor and a complementary treatment for tuberculosis (TB).
- The systematic review analyzed studies on piperine's effects against mycobacteria, focusing on its mechanisms, drug interactions, and antimycobacterial properties.
- Out of 225 articles identified, eight met the inclusion criteria and indicated that piperine exhibits effective anti-TB activity, particularly when used alongside other antimicrobials.
Setting: The increase of multidrug and extensively drug resistant Mycobacterium tuberculosis strains turns the search for new tuberculosis (TB) treatment options of paramount importance.
Objective: In this sense, the present study evaluates the in vitro activity of isoniazid (INH)/rifampicin (RIF)/levofloxacin (LVX) and INH/RIF/linezolid (LNZ) combinations in resistant M. tuberculosis.