Publications by authors named "Sandra S Edwards"
Article Synopsis
- Drosophila genetics is a valuable resource for studying innate immunity, particularly through the behavior of hemocytes, which are fly immune cells that can move and engulf pathogens.
- Hemocytes are crucial for Drosophila development during both embryonic and pupal stages, but there's a lack of effective lab techniques to analyze their movement in controlled environments.
- The research introduces a method to observe hemocyte behavior by stimulating them with ecdysone, revealing changes in cell structure and movement that help understand the underlying biological processes of cell locomotion.
Background: Angiogenesis, the process in which new blood vessels are formed from preexisting ones, is highly dependent on the presence of classical angiogenic factors. Recent evidence suggests that axonal guidance proteins and their receptors can also act as angiogenic regulators. Netrin, a family of laminin-like proteins, specifically Netrin-1 and 4, act via DCC/Neogenin-1 and UNC5 class of receptors to promote or inhibit angiogenesis, depending on the physiological context.
View Article and Find Full Text PDFDisorders in skin wound healing are a major health problem that requires the development of innovative treatments. The use of biomaterials as an alternative of skin replacement has become relevant, but its use is still limited due to poor vascularization inside the scaffolds, resulting in insufficient oxygen and growth factors at the wound site. In this study, we have developed a cell-based wound therapy consisting of the application of collagen-based dermal scaffolds containing mesenchymal stem cells from Wharton's jelly (WJ-MSC) in an immunocompetent mouse model of angiogenesis.
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