Publications by authors named "Sandra Regina Nunes de Andrade Medeiros"
Evaluation of Bauhinia ungulata Essential Oil as a New Acetylcholinesterase Inhibitor from an in silico and in vitro Perspective in the Northern Amazon of Brazil.
Sandra Regina Nunes de Andrade Medeiros Iverson Conrado Bezerra Lucas Aleixo Leal Pedroza Artur José da Silva Regildo Max Gomes Martins
J Oleo Sci
July 2024
The Bauhinia ungulata, also known by its common name "pata de vaca", is one of the species used in Brazil for medicinal purposes, and is commonly used for the treatment of diabetes. In this study, the authors studied the interaction between the chemical constituents which are present in the essential oil of Bauhinia ungulata (EOBU), collected in Boa Vista-RR, Legal Amazon, and their effects on the enzyme acetylcholinesterase (AChE) in the essential oil. The analysis that we perform includes proton magnetic resonance ( H NMR), enzymatic inhibition, molecular docking, in silico toxicity prediction, enrichment analysis, and target prediction for biological interactions.
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- Bauhinia ungulata is explored for its antioxidant properties and potential benefits in managing diabetes, particularly using essential oil extracted from plants in Brazil.
- Gas chromatography revealed key components of the oil, with α-bisabolol, β-Caryophyllene, and Epi-γ-eudesmol being the most prominent, and various antioxidant assays showed significant activity against free radicals.
- The study concludes that the essential oil from Bauhinia ungulata is a strong antioxidant, effectively reducing oxidative stress, which may have implications for alternative diabetes treatments.