ROS-induced autophagy reduces B16F10 melanoma cell proliferative activity.

Cancer is a pathology characterized by increased cell progression and/or reduced programmed cell death. Melanoma shows a rapid increase in cell progression and its resistance to chemotherapy is associated with uncontrolled apoptosis and to mechanisms that increase the flow of the drug out of the cell. The objective of this study was to evaluate the effects of photodynamic therapy (PDT) on the cell proliferation and cellular alterations in B16F10 murine melanoma.

Effects of PACT using phenothiazine-derived drugs and red light on the macrophage x S. aureus interface.

The aim of this study was to evaluate the lethal potential of macrophages infected with Staphylococcus aureus after PACT (Photochemical Antimicrobial Chemotherapy) using phenothiazine derivatives (a solution containing 1:1 methylene blue and O toluidine blue) and laser (660 nm, 40 mW, 60 s, 12 J/cm) or LED (632 ± 2 nm, 145 mW, 40 s, 12 J/cm). Six experimental groups were evaluated: Control Group (untreated); Photosensitizer group (phenothiazines - 12.5 μg/mL); Laser Group; LED Group; Laser PACT Group; and LED PACT Group.