Publications by authors named "Sandra Patricia Palma-Albornoz"
There is evidence that IL-22 and IL-17 participate in the pathogenesis of allergic asthma. To investigate the role of IL-22, we used IL-22 deficient mice (IL-22 KO) sensitized and challenged with ovalbumin (OVA) and compared with wild type (WT) animals exposed to OVA. IL-22 KO animals exposed to OVA showed a decreased number and frequency of eosinophils, IL-5 and IL-13 in the airways, reduced mucus production and pulmonary inflammation.
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- The study investigates the relationship between gut microbiota and lung health, particularly how obesity-induced gut dysbiosis may worsen tuberculosis infection and lung inflammation.
- Using a mouse model of high-fat diet-induced obesity and subsequent TB infection, the researchers found increased susceptibility and inflammation in obese mice.
- The findings emphasize the potential of modifying gut microbiota as a therapeutic strategy for improving responses to tuberculosis, especially in individuals with obesity-related complications.