Telehealth Simulation: Effect on Nurse Learner Knowledge, Confidence, and Attitudes.

Limited research explores the effectiveness of educational interventions in meeting telehealth technology competencies. A combined didactic and simulation intervention was implemented with 66 prelicensure and 15 nurse practitioner students. Telehealth knowledge, confidence, and attitudes were evaluated using the Telemedicine Objective Structured Clinical Exam survey.

Lentivector cryptic splicing mediates increase in CD34+ clones expressing truncated HMGA2 in human X-linked severe combined immunodeficiency.

X-linked Severe Combined Immunodeficiency (SCID-X1) due to IL2RG mutations is potentially fatal in infancy where 'emergency' life-saving stem cell transplant may only achieve incomplete immune reconstitution following transplant. Salvage therapy SCID-X1 patients over 2 years old (NCT01306019) is a non-randomized, open-label, phase I/II clinical trial for administration of lentiviral-transduced autologous hematopoietic stem cells following busulfan (6 mg/kg total) conditioning. The primary and secondary objectives assess efficacy in restoring immunity and safety by vector insertion site analysis (VISA).

Just-in-Time Qualitative Research: Methodological Guidelines Based on the COVID-19 Pandemic Experience.

Background: Methodological guidelines are required to ensure both the rigor and feasibility of just-in-time, qualitative research addressing the human experience and response to the COVID-19 pandemic and major public health crises.

Objectives: This article presents methodological guidelines for just-in-time qualitative research based on our current, pandemic-relevant research.

Methods: The processes followed while conducting two longitudinal, online qualitative studies addressing the lived experience and response to the COVID-19 pandemic were analyzed.

Families of Adolescents with Autism: Facing the Future.

The purpose of this report, drawn from a larger study, was to investigate family adaptation in families of adolescents with autism spectrum disorder and to determine whether family adaptation is influenced by: daily stressors, uncertainty regarding the adolescent's disability, and use of coping strategies on the family's adaptation process. Selection of variables was guided by McCubbin's Family Resilience Model. A total of 115 family members, all members of Interactive Autism Network, participated and completed the study using web-based technology.

Graduate Clinical Nurse Preceptors: Implications for Improved Intra-Professional Collaboration.

Advanced practice nurses have increased in number and public acceptance. Students preparing for these roles require quality clinical education so they are prepared to assume collaborative roles in healthcare settings. Although graduate clinical preceptors have a vitally important role in the clinical education and professional socialization of advanced practice students, there is a paucity of evidence about factors that influence their role commitment.

Bicalutamide plus anastrozole for the treatment of gonadotropin-independent precocious puberty in boys with testotoxicosis: a phase II, open-label pilot study (BATT).

Objective: To evaluate the efficacy, tolerability, and pharmacokinetics of bicalutamide plus anastrozole in young males with testotoxicosis.

Methods: This was a multicenter, open-label, single-arm, 12-month, Phase II pilot trial in 14 males (2-9 years) with testotoxicosis treated with bicalutamide (12.5, 25, 50, or 100 mg) and anastrozole (0.