Publications by authors named "Sandra Ng"
Prospects for the discovery of robust and reproducible biomarkers have improved considerably with the development of sensitive omics platforms that can enable measurement of biological molecules at an unprecedented scale. With technical barriers to success lowering, the challenge is now moving into the analytical domain. Genome-wide discovery presents a problem of scale and multiple testing as standard statistical methods struggle to distinguish signal from noise in increasingly complex biological systems.
View Article and Find Full Text PDFBackground: CLUSTER is a UK consortium focussed on precision medicine research in JIA/JIA-Uveitis. As part of this programme, a large-scale JIA data resource was created by harmonizing and pooling existing real-world studies. Here we present challenges and progress towards creation of this unique large JIA dataset.
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- An interferon gene signature (IGS) is found in about 50% of early rheumatoid arthritis patients and negatively impacts their initial treatment response.
- A multicenter study with 191 patients confirmed that a higher baseline IGS correlates with increased levels of circulating IFN-α and worse clinical outcomes after six months.
- The findings suggest that IFN-α triggers harmful immune responses in patients, highlighting the IGS as a potential biomarker for predicting disease severity and the need for targeted therapies.
Integrating reference datasets (e.g. from high-throughput experiments) with unstructured and manually-assembled information (e.
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