Publications by authors named "Sandra N Clorius"
Purpose: The recognition of those hydronephrotic kidneys which require therapy to preserve renal function remains difficult. We retrospectively compared the 'tissue tracer transit' (TTT) of (99m)Tc-mercaptoacetyltriglycine ((99m)Tc-MAG(3)) with 'response to furosemide stimulation' (RFS) and with 'single kidney function < 40%' (SKF < 40%) to predict functional course and thereby need for surgery.
Methods: Fifty patients with suspected unilateral obstruction and normal contralateral kidney had 115 paired (baseline/follow-up) (99m)Tc-MAG(3) scintirenographies.
Article Synopsis
- - The study investigates the relationship between delayed tissue tracer transit (TTT) of (99m)Tc-MAG3 and functional decline in piglets with surgically induced hydronephrosis, finding that delayed TTT correlates with worsening kidney function and changes in kidney structure.
- - Twenty piglets underwent assessments using magnetic resonance urography (MRU) and diuretic renography (DR) both before and after surgery, revealing that 12 kidneys exhibited delayed TTT post-operation, indicating significant functional and histological changes.
- - The results suggest that delayed TTT in hydronephrosis is not just a marker of reduced kidney function but also suggests alterations in kidney physiology, particularly relating to increased activity of the