Optimizing Telehealth: Leveraging Key Performance Indicators for Enhanced TeleHealth and Digital Healthcare Outcomes (Telemechron Study).

Over the past decade, the use of telehealth has garnered increasing attention. The focus on quality aspects has seen significant growth in tandem with the telehealth expansion. Having useful indicators in this area is becoming increasingly strategic for fully integrating the technology into the health domain.

Under the Tech Umbrella: Assessing the Landscape of Telemedicine Innovations (Telemechron Study).

The expanding role of technology assessment in telemedicine is the focus of this study. An umbrella review has been proposed to delve into emerging themes within telemedicine technology assessment by scrutinizing systematic reviews gathered from PubMed and Scopus. The proposed approach was based on a standard narrative checklist and a qualification process.

Enhancing spatial navigation skills in mild cognitive impairment patients: a usability study of a new version of ANTaging software.

Introduction: Mild Cognitive Impairment (MCI) often presents challenges related to spatial navigation and retention of spatial information. Navigating space involves intricate integration of bodily and environmental cues. Spatial memory is dependent on two distinct frame of reference systems for organizing this information: egocentric and allocentric frames of reference.

Balance Rehabilitation through Robot-Assisted Gait Training in Post-Stroke Patients: A Systematic Review and Meta-Analysis.

Background: Balance impairment is a common disability in post-stroke survivors, leading to reduced mobility and increased fall risk. Robotic gait training (RAGT) is largely used, along with traditional training. There is, however, no strong evidence about RAGT superiority, especially on balance.

Using native fish in eco-genotoxic assessment of heavy metal contamination pollution arising from nearby large Brazilian rivers.

Worldwide water quality has declined progressively due to continuous pollution of aquatic resources by agrochemicals in particular heavy metals. Fish genotoxicity biomarkers are vital to identify and complement chemical parameters for determining environmental risk of adverse effects. Therefore, it was of interest to examine the eco-genotoxicity attributed to water pollution over different stream sections of Brazilian rivers by using (Teleostei: Cichlidae), a neotropical freshwater cichlid fish, as a biological model.

Adapting the World Health Organization rapid Assistive Technology Assessment (rATA) to the Italian context: implementation of a TRAPD-based approach.

Background: Measuring access to assistive technology (AT) has become a global priority. Recently, the World Health Organization (WHO) has developed the rapid assistive technology assessment (rATA), a population-based household survey that measures the use, need, unmet need, and barriers to accessing AT.

Objective: The aim of this paper is to report on the translation and adaptation process undertaken to implement the rATA survey in the Italian context.

A selective Cu complex with 4-fluorophenoxyacetic acid hydrazide and phenanthroline displays DNA-cleaving and pro-apoptotic properties in cancer cells.

The thin line between efficacy and toxicity has challenged cancer therapy. As copper is an essential micronutrient and is important to tumor biology, Cu complexes emerged as an alternative to chemotherapy; however, its biological properties need to be better understood. Thus, we report in vitro the antitumor effects of two Cu complexes named [Cu(4-fh)(phen)(ClO)] (complex 1) and [Cu(4-nh)(phen)(ClO)]·HO (complex 2), in which 4-fh = 4-fluorophenoxyacetic acid hydrazide; 4-nh = 4-nitrobenzoic hydrazide and phen = 1,10-phenanthroline.

Chromosomal Instability and Origin of B Chromosomes in the Amazonian Glass Tetra Moenkhausia oligolepis (Günther, 1864) (Characiformes, Characidae).

B chromosomes occur in different species of the small characid fishes of the genus Moenkhausia. These supernumerary elements, that do not recombine with chromosomes of the standard A complement and follow their own evolutionary mechanism vary in number, morphology, and distribution. Here, we show karyotypic data of individuals of 2 populations of Moenkhausia oligolepis of the Brazilian Amazon (Pedro Correia and Taboquinha streams, Tocantins river basin), both with a diploid number of 50 chromosomes and karyotypic formula of 10m + 32sm + 8a.

Effects of robot-assisted gait training on postural instability in Parkinson's disease: a systematic review.

Introduction: Postural instability is a cardinal feature of Parkinson's disease, together with rest tremor, rigidity and bradykinesia. It is a highly disabling symptom that becomes increasingly common with disease progression and represents a major source of reduced quality of life in patients with Parkinson's disease. Rehabilitation aims to enable patients with Parkinson's disease to maintain their maximum level of mobility, activity and independence.

In vitro and in vivo antitumoral activity of a ternary copper (II) complex.

Recently, a high number of copper derivatives has been evaluated as DNA-targeting metallodrugs, due to the lower toxicity and its potential to cleave DNA. Several strategies have been testing to develop metal compounds effective against tumour cells. In this work, the ternary copper (doxycycline)-(1,10-phenanthroline) complex [Cu(dox)(phen)] was especially designed as an antitumoral drug, previously showing high cytotoxicity and DNA cleavage activity.

Assessment of the genotoxic potential of water courses impacted by wastewater treatment effluents using micronucleus assay in plants from the specie.

Water pollution and the increase in genotoxic consequences in aquatic environments are well documented indicating the necessity and importance of biomonitoring programs. The objective of the present study was to determine the environmental quality of water resources and genotoxic potential of materials present within water samples obtained from the Perdizes River and the Mumbuca Stream, located in a region of discharge of wastewater treatment effluents using micronucleus assay (Trad - MCN). Water samples were collected from different locations up and downstream of the wastewater treatment plant during rainy season and subsequently submitted to physico-chemical analysis and Trad-MCN bioassay.

Health inequalities: a Research Positioning Exercise at the National Institute of Health, Italy.

Background: The Italian National Institute of Health (Istituto Superiore di Sanità, ISS) considers health inequalities (HI) an important area of activity. As the scientific and technical body of the Ministry of Health and the National Health Service, ISS may play a key role to reduce HI. In order to enable ISS in addressing the new and crucial HI challenge, a Research Positioning Exercise was designed and implemented.

Genotoxicity assessment of polluted urban streams using a native fish .

Water quality has declined globally due to increased contamination of aquatic ecosystems. The use of fish genotoxicity biomarkers may improve and complement parameters for environmental risk assessment. The aim of this study was to assess the genotoxicity of samples collected from streams of the Jordão River, a tributary of the Paranaíba River, Brazil with different levels of metal contamination, utilizing a native fish species to determine the sensitivity and viability of implementing a useful, reliable technique for routine biomonitoring programs.

Action of copper(II) complex with β-diketone and 1,10-phenanthroline (CBP-01) on sarcoma cells and biological effects under cell death.

This work reports the biological evaluation of a copper complex of the type [Cu(O-O)(N-N)ClO], in which O-O = 4,4,4-trifluoro-1-phenyl-1,3-butanedione (Hbta) and N-N = 1,10-phenanthroline (phen), whose generic name is CBP-01. The cytotoxic effect of CBP-01 was evaluated by resazurin assay and cell proliferation was determined by MTT assay. DNA fragmentation was analyzed by gel electrophoresis.

Effect of urbanization on the micronucleus frequency in birds from forest fragments.

The urbanization contributes to environment contamination, mainly by the increased vehicle traffic. This intense traffic releases in the air chemical compounds with mutagenic properties that can affect the entire ecosystem. The birds for the flight accumulate air, absorbing gases or particles.

Biomonitoring birds: the use of a micronuclei test as a tool to assess environmental pollutants on coffee farms in southeast Brazil.

Birds have often played an important role as environmental bioindicators, and different species can be useful due to their bioaccumulating capacity. The micronuclei test is a cytologic technique used for accessing DNA and is a biomarker for damage to DNA. This study analysed the Cerrado avian community, especially the efficiency of the blue-black grassquit (Volatinia jacarina) in responding to pesticide contamination in situ on different-sized coffee farms in southeast Brazil.

Integrated monitoring for environmental health impact assessment related to the genotoxic effects of vehicular pollution in Uberlândia, Brazil.

The development of parameters to explore the link between air-related diseases and their significant driving forces is an important aim in terms of national economics and public health. In this study, we did an integrated analysis involving multiple environmental health indicators from Uberlândia, Brazil, registered before and during a period when the Brazilian government reduced taxes on new cars in a bid to bolster local manufacturing. In addition, the present study utilized Driving Force-Pressure-State-Exposure-Effect-Action (DPSEEA) frameworks to evaluate correlations in environmental health indicators over 10 years (2004-2013), in which the Brazilian government reduced vehicle production taxes beginning in 2008.

Assessment of genotoxic, mutagenic, and recombinogenic potential of water resources in the Paranaíba River basin of Brazil: A case study.

Exposure to certain pollutants induces a series of alterations in deoxyribonucleic acid (DNA) that may result in genotoxic/mutagenic effects in exposed individuals. The present study aimed to monitor genotoxic, mutagenic, and recombinogenic potential and consequently water quality in two streams in the Paranaíba River basin in the state of Minas Gerais, Brazil, using two bioindicator fish (Rhamdia quelen and Geophagus brasiliensis). The micronucleus (MN) test and somatic recombination and mutation test (SMART) were employed to assess DNA damage.

Karyoevolutionary Inferences in Enigmatic Taxon Astyanax (Teleostei: Characidae).

Accessing the taxonomy of fish is a basic condition for the conservation of species, and the understanding of their evolutionary relationships. Many Neotropical species of fishes of the order Characiformes are considered incertae sedis because of a lack of consistent evidence of monophyly, with the genus Astyanax among them. With a cytotaxonomic and evolutionary purpose, we compared the karyotype of two species of Astyanax: Astyanax paranae and Astyanax elachylepis.

Toxicological assessment of spinosad: Implications for integrated control of Aedes aegypti using larvicides and larvivorous fish.

Integration of larvivorous fish and biolarvicides at low concentrations to control of mosquito larvae in field situations may result in a safer and more effective tool. However, the usefulness of integrated approach depends upon survival and ecological fitness of fish employed. Thus, the aim of this study was to examine the genotoxic effects of combining different sublethal concentrations of spinosad, a naturally occurring neurotoxic insecticide, with male adult poecilid larvivorous guppy (Poecilia reticulata) and platy (Xiphophorus maculatus) fish on Aedes larvae mosquitos.

Assessment of water quality and genotoxic impact by toxic metals in Geophagus brasiliensis.

This study used the pearl cichlid Geophagus brasiliensis as a bioindicator to survey the health of the aquatic environment on four sites (P1, P2, P3 and P4) of the Mumbuca stream located at Monte Carmelo/MG, Brazil. The selection of different sites was made with reference to the gradient of urban activity and via physicochemical and biological evaluation of water quality and genotoxicity. The water quality index was classified as 'good' for P1 and P4, regular in P2 and 'poor' for P3.

Chromosomal disruption and rearrangements during murine sarcoma development converge to stable karyotypic formation kept by telomerase overexpression.

Background: Tumor initiation presents a complex and unstable genomic landscape; one of the earliest hallmark events of cancer, and its progression is probably based on selection mechanisms under specific environments that lead to functional tumor cell speciation. We hypothesized that viable tumor phenotypes possess common and highly stable karyotypes and their proliferation is facilitated by an attuned high telomerase activity. Very few investigations have focused on the evolution of common chromosomal rearrangements associated to molecular events that result in functional phenotypes during tumor development.

The impact of water pollution on fish species in southeast region of Goiás, Brazil.

The rivers from the region of Catalão, Southeast Goiás State, Brazil, are exposed to intense anthropogenic influences including agricultural activities, industry, and urban waste. The aim of this study was to determine the severity of water pollution by conducting an experiment involving in situ biomonitoring of water constituents on genotoxicity in fish inhabiting these sites. The genotoxicity of three sites of the region were analyzed utilizing the micronucleus (MN) test.

Genotoxic evaluation of the River Paranaíba hydrographic basin in Monte Carmelo, MG, Brazil, by the Tradescantia micronucleus.

Pollutants have adverse effects on human health and on other organisms that inhabit or use water resources. The aim of the present study was to assess the environmental quality of three watercourses in Monte Carmelo, MG, Brazil, using the micronucleus test on Tradescantia. For each treatment, 15 plants were exposed to water samples for 24 h.