Publications by authors named "Sandra Mignot"
J Cell Mol Med
December 2020
Article Synopsis
- In haemophilia, repeated bleeding into joints causes a specific type of joint damage known as haemophilic arthropathy (HA), which is influenced by resident cells like fibroblast-like synoviocytes (FLS) coming into contact with blood.
- Researchers found that HA-FLS exhibit a different cytokine secretion profile compared to non-HA FLS, showing higher levels of cytokines related to innate immunity.
- The study discovered significant differences in the expression of 30 miRNAs between HA and non-HA FLS that are linked to inflammatory processes, indicating that blood exposure may lead to long-lasting changes in miRNA and contribute to the development of HA.
