Publications by authors named "Sandra Mesliniene"
Objective: To review and assess the role of vitamin D in the onset, progression, and relapse of multiple sclerosis (MS), based on evidence acquired from the analysis of preclinical, observational, and interventional studies.
Methods: All English language literature in MEDLINE (January 1969 through April 2012) was searched for observational and interventional studies on the dosage effect of vitamin D on the onset, progression, and relapse rate of MS. The medical subject heading (MeSH) terms used in the search included Vitamin D and Multiple Sclerosis.
Article Synopsis
- - Smokers have lower levels of HDL cholesterol and apo A-I, prompting researchers to explore how the aryl hydrocarbon receptor (AhR) influences apo A-I gene expression.
- - In laboratory tests, exposure to AhR agonists like benzo(a)pyrene reduced apo A-I production and mRNA levels, while nicotine showed no impact on apo A-I secretion.
- - The study identified a specific DNA sequence (xenobiotic response element) that plays a role in the regulation of apo A-I gene expression, suggesting that compounds from cigarette smoke can lead to lower cholesterol levels in smokers.