Publications by authors named "Sandra M Poudrier"
Article Synopsis
- Metalloendopeptidase ADAM-Like Decysin 1 (ADAMDEC1) is an anti-inflammatory enzyme mainly found in the gastrointestinal tract, specifically in colonic mucosal PDGFRα cells.
- Recent findings indicate a high expression of Adamdec1 in these cells during DSS-induced colitis in mouse models, contrasting with minimal expression in macrophages.
- The prevalence of ADAMDEC1 in PDGFRα cells in both mouse and human Crohn's disease suggests its potential as a target for diagnosing and treating intestinal inflammation.
Subepithelial platelet-derived growth factor receptor alpha (PDGFRα)+ cells found in the colonic mucosal tissue come in close contact with epithelial cells, immune cells, neurons, capillaries, and lymphatic networks. Mucosal subepithelial PDGFRα+ cells (MuPαC) are important regulators in various intestinal diseases including fibrosis and inflammation. However, the transcriptome of MuPαC has not yet been elucidated.
View Article and Find Full Text PDFBackground & Aims: Interstitial cells of Cajal (ICCs) and pancreatic β cells require receptor tyrosine kinase (KIT) to develop and function properly. Degeneration of ICCs is linked to diabetic gastroparesis. The mechanisms linking diabetes and gastroparesis are unclear, but may involve microRNA (miRNA)-mediated post-transcriptional gene silencing in KIT cells.
View Article and Find Full Text PDFIntestinal obstructions, that impede or block peristaltic movement, can be caused by abdominal adhesions and most gastrointestinal (GI) diseases including tumorous growths. However, the cellular remodeling mechanisms involved in, and caused by, intestinal obstructions are poorly understood. Several animal models of intestinal obstructions have been developed, but the mouse model is the most cost/time effective.
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