Optimization of the parameters of a method for computer-aided detection of perfusion deficiencies in brain images.

Objective: Simulated data from the recent Institute of Physics and Engineering in Medicine audit of quantitative cerebral perfusion were used to optimize the parameters of eigenimage analysis, a method for computer-aided detection.

Methods: Twenty normal images provided by the audit were registered to the International Consortium for Brain Mapping 452 template using HERMES multimodality software and normalized to total counts. Six normal atlases were formed using the mean image and from zero to five eigenimages.

Quantification of [123I]FP-CIT SPECT brain images: an accurate technique for measurement of the specific binding ratio.

Purpose: A technique is described for accurate quantification of the specific binding ratio (SBR) in [(123)I]FP-CIT SPECT brain images.

Methods: Using a region of interest (ROI) approach, the SBR is derived from a measure of total striatal counts that takes into account the partial volume effect. Operator intervention is limited to the placement of the striatal ROIs, a task facilitated by the use of geometrical template regions.