Publications by authors named "Sandra Lopes-De-Souza"
Article Synopsis
- Breastfeeding is crucial for neurodevelopment and early weaning has lasting negative effects on the mother-child bond and can lead to stress during infancy.
- Early weaning disrupts neural mechanisms governing feeding behavior, leading to issues like overeating, increased body weight, and changes in hormonal regulation.
- The review explores interventions like medication, herbal remedies, calcium, and physical activity to potentially mitigate the adverse effects of early weaning on feeding behavior control.
Background/objectives: Migraine is a disease that stands out for its high prevalence and socioeconomic costs. It involves the entire trigeminovascular system, the signaling substances, and their targets. However, the role of meningeal mast cells in migraine is still unclear.
View Article and Find Full Text PDFLetter to the Editor: Ketogenic diet time-dependently prevents nonalcoholic fatty liver disease through upregulating the expression of antioxidant protein metallothionein-2.
Clin Nutr
August 2024
Article Synopsis
- Nutrition is critical for brain development, especially in infants, with vitamin B12 being essential for the motor nervous system.
- The research involved a systematic review of studies using databases like PubMed and Scopus, ultimately analyzing data from 1,559 participants across diverse geographical locations.
- Results indicate that low vitamin B12 levels negatively influence motor development in infants, and supplementation may help improve this aspect, highlighting the need for public policies to support effective interventions.
Comment on "Prognosis of patients with coexisting obesity and malnutrition after ischemic stroke: A cohort study" Clinical Nutrition.
Clin Nutr
August 2024
Comment on "Adherence to the ultra-processed dietary pattern and risk of depressive outcomes: Findings from the NutriNet Brasil cohort study and an updated systematic review and meta-analysis" Clinical Nutrition.
Clin Nutr ESPEN
June 2024
Comment on Assessment of muscle endocrine function and inflammatory signalling in male school children following a physical activity programme. Clinical Nutrition 2024.
Clin Nutr
June 2024
Letter to the editor: Iron deficiency in pernicious anemia: Specific features of iron deficient patients and preliminary data on response to iron supplementation.
Clin Nutr
June 2024
Letter to the editor: The association between human milk fatty acid composition in mothers with an elevated body mass index and infant growth changes.
Clin Nutr
February 2024
Comment on "Implementation of STRONGkids for identifying nutritional risk in outpatients of child health care clinics: Results of a multicentre study" Clinical Nutrition 2023.
Clin Nutr
April 2024
Context: Early adverse experience can have a long-term effect on growth and development and negative repercussions into adulthood. Among the various consequences of undernutrition is depression.
Objective: The present work aimed to evaluate the relationship between early-life undernutrition and depression in adult life.
Therapeutic advances for treating memory impairments in perinatal brain injuries with implications for cerebral palsy: a systematic review and meta-analysis of preclinical studies.
Exp Neurol
July 2023
Cerebral palsy (CP) is a neurodevelopmental disorder caused by damage to the immature brain. CP is considered the main cause of physical disability in childhood. Studies have shown that memory function and emotional behaviour are significantly impaired in CP.
View Article and Find Full Text PDFLetter to editor: Comment on "sarcopenic obesity is associated with cognitive impairment in community-dwelling older adults: The bunkyo health study" clinical nutrition 2022.
Clin Nutr
September 2022
Letter to the editor: Impact of COVID-19 in nutritional and functional status of survivors admitted in intensive care units during the first outbreak. Preliminary results of the NUTRICOVID study.
Clin Nutr
December 2022
Obesogenic diets are known to induce obesity and changes in food intake in experimental animals. Obesity negatively affects the peripheral metabolism and neural aspects, such as changes in eating behavior. In obese animals, dopamine (DA) receptor levels are reduced.
View Article and Find Full Text PDFUnlabelled: Childhood obesity is a serious public health problem. Childhood obesity and overweight are associated with the appearance of coordination deficit disorder and can cause impaired motor performance. We searched online databases for all related articles using comprehensive international databases from the Medline PubMed Institute, Web of Science, ScienceDirect, SCOPUS, and PsycINFO up to December 20, 2020.
View Article and Find Full Text PDFMaternal separation in the light or dark phase of the circadian cycle has different effects on the corticosterone levels and anxiety-like behavior in male adult rats.
Physiol Behav
April 2022
Article Synopsis
- Maternal care is crucial for the growth and development of offspring, with the light phase of the circadian cycle being the most caring time for the dam.
- A study compared the effects of maternal separation during the light versus dark phases on adult male Wistar rats, measuring behavioral and physiological responses.
- Results indicated that rats separated in the light phase showed increased anxiety and specific hormonal changes, while differences in food intake and adipose tissue weight were noted across the experimental groups.
Evidence shows that metabolic syndrome (MS) is associated with a greater risk of developing Parkinson's disease (PD) because of the increase in oxidative stress levels along with other factors such as neuroinflammation and mitochondrial dysfunction. However, because some studies have reported that MS is associated with a lower risk of PD, the relationship between MS and PD should be investigated. This study aimed to investigate the effect of MS on PD.
View Article and Find Full Text PDFEnvironmental factors interfere in the neural plasticity processes. Among these, malnutrition in the early stages of life stands out as one of the main non-genetic factors that can interfere in the morphofunctional development of the nervous system. Furthermore, sensory stimulation from enriched environments (EE) also interferes with neural development.
View Article and Find Full Text PDFVitamin D is a fat-soluble vitamin that plays a role not only in calcium homeostasis, but also in several other functions, including cell growth and immune functions, and is considered a neurosteroid. Vitamin D deficiency is highly prevalent worldwide and has been suggested to be associated with an increased risk of emotional disorders. Therefore, the association between vitamin D levels and psychophysiological disorders, such as depression, anxiety, and mood, has been investigated.
View Article and Find Full Text PDFAdverse experiences that occur during the early stages of life can have permanent repercussions in adulthood. Among these experiences, early weaning is one that can alter the molecular, cellular, and behavior patterns in later life. Centered on this fact, the objective of the current study was to evaluate the effect of early weaning at 15 days of life of Wistar rats on their feeding behavior and if the opioidergic system blockade would cause a reversal of these outcomes.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how hunger and satiety are regulated in newborn rats by examining gene expression of specific peptides and nutrient sensors in the hypothalamus at 10 and 18 days old.
- The researchers looked at male rats in different groups (Fasting, Water, Milk, Gavage) to assess changes in gene expression related to hunger cues and energy sensing, specifically Neuropeptide Y (NPY), Agouti-related peptide (AgRP), proopiomelanocortin (POMC), cocaine-and amphetamine-regulated transcript (CART), and energy sensors mTOR and AMPK.
- Results indicated that while fasting increased AMPK expression and decreased mTOR at both ages, changes in NPY and AgRP were more pronounced
The scope of this article is to identify the repercussions of the effect of memory stimulation in healthy elderly individuals. It is an integrative review of the literature, namely of articles published in the last seven years in English, Portuguese and Spanish. The selection was performed through cross-checking of key words: health of the elderly, memory and cognition in the Lilacs, Medline and IBECS databases.
View Article and Find Full Text PDFEarly life stress induced by maternal separation during lactation alters the eating behavior and serotonin system in middle-aged rat female offspring.
Pharmacol Biochem Behav
May 2020
Article Synopsis
- Stressful early life events, like maternal separation, disrupt feeding behavior and the serotonergic system in adult animals.
- The study focused on middle-aged female rats separated from their mothers for two weeks, showing altered eating patterns tied to their serotonin levels.
- Results indicated that maternal separation led to decreased food intake and altered meal behaviors, with a link to increased serotonin receptor activity in the brain, suggesting long-term impacts of early stress on behavior.