Publications by authors named "Sandra Krueger"
Osteogenesis imperfecta (OI) is a collagen-related bone disorder characterized by fragile osteopenic bone and muscle weakness. We have previously shown that the soluble activin receptor type IIB decoy (sActRIIB) molecule increases muscle mass and improves bone strength in the mild to moderate G610C mouse model of OI. The sActRIIB molecule binds multiple transforming growth factor-β (TGF-β) ligands, including myostatin and activin A.
View Article and Find Full Text PDFChimeric antigen receptor (CAR) T cell therapy has emerged as an attractive strategy for cancer immunotherapy. Despite remarkable success for hematological malignancies, excessive activity and poor control of CAR T cells can result in severe adverse events requiring control strategies to improve safety. This work illustrates the feasibility of a zinc finger-based inducible switch system for transcriptional regulation of an anti-CD20 CAR in primary T cells providing small molecule-inducible control over therapeutic functions.
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- Predictive in vitro test methods can potentially reduce the need for in vivo studies in pediatric drug testing by simulating drug release in children's gastrointestinal systems.
- The study aimed to create a novel dissolution model that accurately reflects pediatric gastrointestinal physiology and uses small fluid volumes and bicarbonate-based media for testing.
- Results from experiments using this model showed that a valproate-extended release formulation released the drug in a controlled manner over 12 hours, aligning well with existing product information and earlier in vivo study results.
Strategies to increase milk volume in mothers of VLBW infants.
MCN Am J Matern Child Nurs
October 2015
The provision of breast milk to premature VLBW infants is associated with significant health benefits. Unfortunately, the delivery of breast milk to these vulnerable infants is often limited due to insufficient maternal milk supply. Several interventions have been investigated with respect to increasing milk volume in mothers of VLBW infants but confusion exists concerning the interventions' effectiveness.
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- Emotional expression is crucial for coping with stress in cancer patients, and men often express emotions differently than women, facing unique social barriers.
- A study with 41 men and 41 women showed a trend of women being more emotionally expressive, but both genders had similar perceptions of social constraints on expression.
- Men were found to be more impacted by social constraints from their spouse or partner, suggesting that social context might be more critical than gender differences in emotional expression.