Double-blind fluoxetine trial in comorbid MDD-CUD youth and young adults.

Objective: This study compared the acute phase (12-week) efficacy of fluoxetine versus placebo for the treatment of the depressive symptoms and the cannabis use of adolescents and young adults with comorbid major depression (MDD) and a cannabis use disorder (CUD) (cannabis dependence or cannabis abuse). We hypothesized that fluoxetine would demonstrate efficacy versus placebo for the treatment of the depressive symptoms and the cannabis use of adolescents and young adults with comorbid MDD/CUD.

Methods: We conducted the first double-blind placebo-controlled study of fluoxetine in adolescents and young adults with comorbid MDD/CUD.

Corneal flap complications in refractive surgery: Part 1: development of an experimental animal model.

Purpose: To report the outcome, learning curve, and complication rates of an experimental animal model for corneal flaps in refractive surgery.

Setting: Magill Research Center for Vision Correction, Storm Eye Institute, Charleston, South Carolina, USA.

Methods: Corneal flaps with a nasal or a temporal hinge were created in 190 eyes of 95 Dutch Belted rabbits using the Automated Corneal Shaper microkeratome (Bausch & Lomb Surgical).

Effects of task structure on category priming in patients with Parkinson's disease and in healthy individuals.

Lexical decision tasks have been used to study both shifts of attention and semantic processing in Parkinson's Disease (PD). Whereas other laboratories have reported normal levels of semantic priming among PD patients, our laboratory has reported abnormally large levels. In this study, two experiments were performed to determine the influence of task structure on the extent of semantic priming during lexical decision-making and pronunciation tasks among PD patients and neurologically healthy controls.