Publications by authors named "Sandra Fontanals Martinez"
Introduction: The increased risk of severe and life-threatening toxicity in patients with dihydropyridine dehydrogenase deficiency, under treatment with fluoropyrimidines, has been widely studied. An up-to-date overview of systematic reviews summarizing existing literature can add value by highlighting most relevant information and supports decision-making regarding treatment in dihydropyridine dehydrogenase deficient patients. The main objective of this overview is to identify published systematic reviews on the association between germline variations in the DPYD gene and fluoropyrimidine toxicity.
View Article and Find Full Text PDFIntroduction: The increased risk of severe and life-threatening toxicity in patients with dihydropyridine dehydrogenase (DPD) deficiency, under treatment with fluoropyrimidines, has been widely studied. An up-to-date overview of systematic reviews summarizing existing literature can add value by highlighting most relevant information and supports decision-making regarding treatment in DPD deficient patients. The main objective of this overview of systematic reviews is to identify published systematic reviews on the association between germline variations in the DPYD gene and fluoropyrimidine toxicity.
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- * A case study of a 72-year-old woman with renal cell carcinoma demonstrated significant drug interactions between everolimus and her other medications, carbamazepine and phenytoin, leading to initial underexposure to everolimus.
- * Therapeutic drug monitoring (TDM) played a key role in adjusting her dose of everolimus, successfully raising plasma levels from 3.7 ng/ml to 10.8 ng/ml, emphasizing the need for careful management of drug interactions to optimize treatment efficacy.